Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CES2 | O00748 | 6/20 | 0.55 |
| ▸ | CES1 | P23141 | 6/20 | 0.55 |
| ▸ | BCHE | P06276 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.31 |
| ▸ | HPGD | P15428 | 1/20 | 0.31 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.31 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.30 |
| ▸ | GAA | P10253 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6604138 | 0.83 | CES2 (0.57) | CES2CES1BCHEALDH1A1HPGD | |
| SCHEMBL3247401 | 0.76 | CES2 (0.57) | CES2CES1ALDH1A1 | |
| SCHEMBL8975156 | 0.74 | CES2 (0.54) | CES2CES1BCHEALDH1A1HPGD | |
| SCHEMBL29775631 | 0.73 | CES2 (0.67) | CES2CES1BCHEALDH1A1HPGD | |
| SCHEMBL671906 | 0.73 | CES2 (0.67) | CES2CES1BCHEALDH1A1HPGD | |
| SCHEMBL2373430 | 0.72 | CES2 (0.59) | CES2CES1BCHEALDH1A1HPGD | |
| SCHEMBL6605209 | 0.72 | POLB (0.37) | CES2CES1HPGD | |
| SCHEMBL1760850 | 0.72 | CES2 (0.73) | CES2CES1BCHEALDH1A1HPGD | |
| SCHEMBL4444760 | 0.70 | CES2 (0.70) | CES2CES1BCHEALDH1A1HPGD | |
| SCHEMBL241797 | 0.70 | CES2 (0.70) | CES2CES1BCHEALDH1A1MAP2K1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1102757-B1 | SUBSTITUTED OXAZOLE AND THIAZOLE DERIVATIVES AS HPPAR GAMMA AND HPPAR ALPHA ACTIVATORS | GLAXO GROUP LTD (GB) | 2004-04-14 | — | — | EP | disclosed |
| US-6498174-B1 | AGONISTS TO PEROXISOME PROLIFERATOR-ACTIVATED RECEPTORS; MODULATING BLOOD GLUCOSE AND LIPID LEVELS; REDUCING DYSLIPIDEMIA AND HYPERINSULINEMIA ASSOCIATED WITH IMPAIRED GLUCOSE TOLERANCE OR METABOLIC SYNDROME | SMITHKLINE BEECHAM CORPORATION | 2002-12-24 | — | — | US | disclosed |
| EP-1102757-A1 | SUBSTITUTED OXAZOLE AND THIAZOLE DERIVATIVES AS HPPAR GAMMA AND HPPAR ALPHA ACTIVATORS | GLAXO GROUP LIMITED (GB) | 2001-05-30 | — | — | EP | disclosed |
| WO-2000008002-A1 | SUBSTITUTED OXAZOLES AND THIAZOLES DERIVATIVES AS hPPAR GAMMA AND hPPAR ALPHA ACTIVATORS | GLAXO GROUP LIMITED (GB) | 2000-02-17 | — | — | WO | disclosed |