Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 6/20 | 0.60 |
| ▸ | HTR2C | P28335 | 4/20 | 0.60 |
| ▸ | HTR2B | P41595 | 3/20 | 0.60 |
| ▸ | P2RX7 | Q99572 | 2/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 4/20 | 0.36 |
| ▸ | CLK1 | P49759 | 1/20 | 0.36 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.34 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.34 |
| ▸ | STAT6 | P42226 | 1/20 | 0.34 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.34 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.33 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.33 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.33 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.33 |
| ▸ | RPS6KA5 | O75582 | 1/20 | 0.33 |
| ▸ | HTR1A | P08908 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Ammonia Solution, Strong SCHEMBL905906 | 0.81 | HTR2A (0.66) | HTR2AHTR2CHTR2BCLK1DYRK1A | |
| SCHEMBL905902 | 0.75 | HTR2C (1.00) | HTR2AHTR2CHTR2BCYP1A2CYP3A4 | |
| SCHEMBL905948 | 0.74 | HTR2A (0.62) | HTR2AHTR2CHTR2BCYP3A4HIF1A | |
| SCHEMBL21245260 | 0.73 | P2RX7 (0.52) | P2RX7RPS6KA5MAPTHASPIN | |
| Fumaric Acid SCHEMBL6605771 | 0.71 | HTR2A (0.54) | HTR2AHTR2CHTR2BHTR1A | |
| SCHEMBL21245175 | 0.70 | P2RX7 (0.52) | P2RX7RPS6KA5HASPIN | |
| Ammonia Solution, Strong SCHEMBL905803 | 0.69 | HTR2A (0.66) | HTR2AHTR2CHTR2BHASPIN | |
| SCHEMBL29720987 | 0.68 | GRM2 (0.50) | HTR2AHTR2CHTR2BCYP1A2HTR1A | |
| Fumaric Acid SCHEMBL6607435 | 0.67 | HTR2C (0.80) | HTR2AHTR2CHTR2B | |
| Fumaric Acid SCHEMBL6605773 | 0.67 | HTR2C (0.80) | HTR2AHTR2CHTR2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1109809-B1 | PYRROLOQUINOLINES FOR TREATMENT OF OBESITY | CEREBRUS PHARM LTD (GB) | 2004-11-17 | — | — | EP | disclosed |
| US-6365598-B1 | FOR THERAPY AND PROPHYLAXIS OF DISORDERS OF THE CENTRAL NERVOUS SYSTEM; DAMAGE TO THE CENTRAL NERVOUS SYSTEM; CARDIOVASCULAR DISORDERS; GASTROINTESTINAL DISORDERS; DIABETES INSIPIDUS; AND SLEEP APNEA | VERNALIS RESEARCH LIMITED (GB) | 2002-04-02 | — | — | US | disclosed |