Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 6/20 | 0.52 |
| ▸ | POLB | P06746 | 2/20 | 0.52 |
| ▸ | CLK1 | P49759 | 1/20 | 0.51 |
| ▸ | ROCK1 | Q13464 | 2/20 | 0.49 |
| ▸ | GRK5 | P34947 | 1/20 | 0.47 |
| ▸ | GSK3A | P49840 | 1/20 | 0.47 |
| ▸ | GSK3B | P49841 | 1/20 | 0.47 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 4/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.47 |
| ▸ | CDC7 | O00311 | 1/20 | 0.46 |
| ▸ | DBF4 | Q9UBU7 | 1/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.44 |
| ▸ | PARP1 | P09874 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.43 |
| ▸ | THRB | P10828 | 1/20 | 0.43 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6606889 | 0.93 | PARP1 (0.51) | MAPTPOLBNR1H4MEN1KMT2A | |
| SCHEMBL6602409 | 0.90 | MAPT (0.51) | MAPTPOLBNR1H4MEN1KMT2A | |
| SCHEMBL6607030 | 0.90 | NR1H4 (0.62) | MAPTPOLBCLK1NR1H4MEN1 | |
| SCHEMBL6604450 | 0.88 | ROCK1 (0.54) | MAPTPOLBCLK1ROCK1GRK5 | |
| SCHEMBL6603227 | 0.86 | MAPT (0.58) | MAPTPOLBNR1H4MEN1KMT2A | |
| SCHEMBL6604870 | 0.84 | MAPT (0.52) | MAPTPOLBCLK1ROCK1MEN1 | |
| SCHEMBL6604075 | 0.84 | IRAK4 (0.56) | MAPTPOLBROCK1NR1H4MEN1 | |
| SCHEMBL6606883 | 0.80 | PARP1 (0.51) | MAPTPOLBNR1H4MEN1KMT2A | |
| SCHEMBL7723576 | 0.78 | MAPT (0.53) | MAPTPOLBCLK1ROCK1MEN1 | |
| SCHEMBL6602401 | 0.78 | MAPT (0.51) | MAPTPOLBNR1H4MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1102535-A4 | COMPOUNDS AND METHODS | SMITHKLINE BEECHAM CORP (US) | 2004-09-29 | — | — | EP | disclosed |
| EP-1102535-A2 | COMPOUNDS AND METHODS | SmithKline Beecham Corporation (US) | 2001-05-30 | — | — | EP | disclosed |
| WO-2000006085-A2 | COMPOUNDS AND METHODS | SMITHKLINE BEECHAM CORPORATION (US) | 2000-02-10 | — | — | WO | disclosed |