Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MCHR1 | Q99705 | 10/20 | 0.57 |
| ▸ | MAPT | P10636 | 3/20 | 0.54 |
| ▸ | TP53 | P04637 | 3/20 | 0.52 |
| ▸ | WNT3A | P56704 | 1/20 | 0.51 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.50 |
| ▸ | HTR2C | P28335 | 1/20 | 0.49 |
| ▸ | NPC1 | O15118 | 1/20 | 0.48 |
| ▸ | PPARG | P37231 | 1/20 | 0.48 |
| ▸ | RAB9A | P51151 | 1/20 | 0.48 |
| ▸ | NCOA2 | Q15596 | 1/20 | 0.48 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.48 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.48 |
| ▸ | ACKR3 | P25106 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6602070 | 0.87 | MCHR1 (0.67) | MCHR1MAPTTP53WNT3ARXFP1 | |
| SCHEMBL6921907 | 0.84 | MCHR1 (0.80) | MCHR1HTR2C | |
| SCHEMBL6605524 | 0.82 | KMT2A (0.68) | MCHR1MAPTTP53SMN1; SMN2NPC1 | |
| SCHEMBL6602810 | 0.80 | MCHR1 (0.54) | MCHR1MAPTSMN1; SMN2HTR2CNPC1 | |
| SCHEMBL6609574 | 0.80 | MCHR1 (0.63) | MCHR1SMN1; SMN2HTR2CNPC1RAB9A | |
| SCHEMBL6901278 | 0.80 | MCHR1 (0.60) | MCHR1HTR2C | |
| SCHEMBL6898088 | 0.80 | MCHR1 (0.67) | MCHR1TP53SMN1; SMN2HTR2CNPC1 | |
| SCHEMBL6896989 | 0.80 | MCHR1 (0.67) | MCHR1TP53SMN1; SMN2HTR2CNPC1 | |
| SCHEMBL6603809 | 0.79 | MCHR1 (0.54) | MCHR1MAPTSMN1; SMN2HTR2CNPC1 | |
| SCHEMBL6603140 | 0.79 | MCHR1 (0.54) | MCHR1MAPTHTR2CKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1102535-A4 | COMPOUNDS AND METHODS | SMITHKLINE BEECHAM CORP (US) | 2004-09-29 | — | — | EP | claimed |
| EP-1102535-A2 | COMPOUNDS AND METHODS | SmithKline Beecham Corporation (US) | 2001-05-30 | — | — | EP | claimed |
| WO-2000006085-A2 | COMPOUNDS AND METHODS | SMITHKLINE BEECHAM CORPORATION (US) | 2000-02-10 | — | — | WO | claimed |
| EP-1102535-A4 | COMPOUNDS AND METHODS | SMITHKLINE BEECHAM CORP (US) | 2004-09-29 | — | — | EP | disclosed |
| EP-1102535-A2 | COMPOUNDS AND METHODS | SmithKline Beecham Corporation (US) | 2001-05-30 | — | — | EP | disclosed |
| WO-2000006085-A2 | COMPOUNDS AND METHODS | SMITHKLINE BEECHAM CORPORATION (US) | 2000-02-10 | — | — | WO | disclosed |