Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2C | P28335 | 18/20 | 1.00 |
| ▸ | HTR2A | P28223 | 17/20 | 1.00 |
| ▸ | HTR2B | P41595 | 9/20 | 1.00 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | GMNN | O75496 | 1/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.42 |
| ▸ | MMP2 | P08253 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | MMP9 | P14780 | 1/20 | 0.42 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.42 |
| ▸ | MMP8 | P22894 | 1/20 | 0.42 |
| ▸ | CCR1 | P32246 | 1/20 | 0.42 |
| ▸ | THPO | P40225 | 1/20 | 0.42 |
| ▸ | MTOR | P42345 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6604307 | 0.81 | HTR2C (1.00) | HTR2CHTR2AHTR2BCYP3A4 | |
| SCHEMBL6603614 | 0.81 | HTR2C (1.00) | HTR2CHTR2AHTR2BCYP3A4 | |
| SCHEMBL6605040 | 0.81 | HTR2C (1.00) | HTR2CHTR2AHTR2BCYP3A4 | |
| Hydrochloric Acid SCHEMBL6607981 | 0.80 | HTR2C (0.97) | HTR2CHTR2AHTR2BCYP3A4 | |
| Hydrochloric Acid SCHEMBL6604400 | 0.80 | HTR2C (0.97) | HTR2CHTR2AHTR2BCYP3A4 | |
| Ammonia Solution, Strong SCHEMBL6604735 | 0.79 | HTR2A (0.66) | HTR2CHTR2AHTR2BLMNAKDM4E | |
| SCHEMBL25818081 | 0.79 | HTR2C (0.65) | HTR2CHTR2AHTR2B | |
| SCHEMBL906124 | 0.77 | HTR2A (1.00) | HTR2CHTR2AHTR2BCYP3A4CCR1 | |
| Phenanthroline SCHEMBL27963166 | 0.73 | CCR1 (0.61) | HTR2CHTR2AHTR2BLMNAKDM4E | |
| SCHEMBL7983996 | 0.73 | HTR2C (0.63) | HTR2CHTR2AHTR2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1109809-B1 | PYRROLOQUINOLINES FOR TREATMENT OF OBESITY | CEREBRUS PHARM LTD (GB) | 2004-11-17 | — | — | EP | disclosed |
| US-6365598-B1 | FOR THERAPY AND PROPHYLAXIS OF DISORDERS OF THE CENTRAL NERVOUS SYSTEM; DAMAGE TO THE CENTRAL NERVOUS SYSTEM; CARDIOVASCULAR DISORDERS; GASTROINTESTINAL DISORDERS; DIABETES INSIPIDUS; AND SLEEP APNEA | VERNALIS RESEARCH LIMITED (GB) | 2002-04-02 | — | — | US | disclosed |