Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 4/20 | 0.66 |
| ▸ | HTR2C | P28335 | 4/20 | 0.66 |
| ▸ | HTR2B | P41595 | 3/20 | 0.66 |
| ▸ | CCR1 | P32246 | 3/20 | 0.44 |
| ▸ | CCR5 | P51681 | 3/20 | 0.44 |
| ▸ | CCR8 | P51685 | 3/20 | 0.44 |
| ▸ | LMNA | P02545 | 3/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.44 |
| ▸ | GMNN | O75496 | 1/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.44 |
| ▸ | MMP2 | P08253 | 1/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.44 |
| ▸ | MMP9 | P14780 | 1/20 | 0.44 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Ammonia Solution, Strong SCHEMBL6603622 | 0.79 | HTR2A (0.67) | HTR2AHTR2CHTR2BLMNAKDM4E | |
| SCHEMBL6604727 | 0.79 | HTR2C (1.00) | HTR2AHTR2CHTR2BCCR1CCR5 | |
| Hydrochloric Acid SCHEMBL6607986 | 0.78 | HTR2A (0.66) | HTR2AHTR2CHTR2BLMNAKDM4E | |
| SCHEMBL7771626 | 0.76 | MTNR1A (0.60) | HTR2AHTR2CHTR2BMTNR1AL3MBTL1 | |
| Ammonia Solution, Strong SCHEMBL906126 | 0.75 | HTR2A (0.70) | HTR2AHTR2CHTR2BCCR1CCR8 | |
| SCHEMBL27252002 | 0.70 | HTR2A (0.48) | HTR2AHTR2CHTR2BCCR1CCR5 | |
| SCHEMBL28990232 | 0.69 | BACE1 (0.46) | GRM2 | |
| SCHEMBL12384269 | 0.69 | SLC6A4 (0.39) | HTR2AHTR2CGRM2 | |
| SCHEMBL809908 | 0.68 | LMNA (0.50) | HTR2AHTR2CHTR2BCCR1CCR5 | |
| Phenanthroline SCHEMBL34468931 | 0.68 | CCR1 (0.94) | CCR1CCR5CCR8LMNAKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1109809-B1 | PYRROLOQUINOLINES FOR TREATMENT OF OBESITY | CEREBRUS PHARM LTD (GB) | 2004-11-17 | — | — | EP | disclosed |
| US-6365598-B1 | FOR THERAPY AND PROPHYLAXIS OF DISORDERS OF THE CENTRAL NERVOUS SYSTEM; DAMAGE TO THE CENTRAL NERVOUS SYSTEM; CARDIOVASCULAR DISORDERS; GASTROINTESTINAL DISORDERS; DIABETES INSIPIDUS; AND SLEEP APNEA | VERNALIS RESEARCH LIMITED (GB) | 2002-04-02 | — | — | US | disclosed |