Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TACR1 | P25103 | 11/20 | 0.65 |
| ▸ | KDM1A | O60341 | 2/20 | 0.48 |
| ▸ | MAOA | P21397 | 2/20 | 0.48 |
| ▸ | MAOB | P27338 | 1/20 | 0.48 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7032818 | 1.00 | TACR1 (0.65) | TACR1KDM1AMAOAMAOBHCRTR2 | |
| SCHEMBL7594455 | 0.87 | TACR1 (0.50) | TACR1HCRTR2 | |
| SCHEMBL7594451 | 0.87 | TACR1 (0.50) | TACR1HCRTR2 | |
| SCHEMBL7867202 | 0.86 | TACR1 (0.60) | TACR1 | |
| SCHEMBL7591379 | 0.86 | TACR1 (0.49) | TACR1HCRTR2 | |
| SCHEMBL7137909 | 0.86 | TACR1 (0.51) | TACR1 | |
| SCHEMBL7135463 | 0.86 | TACR1 (0.51) | TACR1 | |
| SCHEMBL7133654 | 0.86 | TACR1 (0.60) | TACR1 | |
| SCHEMBL8708427 | 0.86 | TACR1 (0.51) | TACR1 | |
| SCHEMBL7864432 | 0.86 | TACR1 (0.58) | TACR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1175417-B1 | SUBSTITUTED BENZOLACTAM COMPOUNDS | PFIZER PROD INC (US) | 2004-01-07 | — | — | EP | disclosed |
| EP-0840732-B1 | SUBSTITUTED BENZOLACTAM COMPOUNDS AS SUBSTANCE P ANTAGONISTS | PFIZER (US) | 2001-03-07 | — | — | EP | disclosed |