Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1D | P28221 | 14/20 | 0.77 |
| ▸ | HTR1B | P28222 | 14/20 | 0.77 |
| ▸ | HTR1A | P08908 | 4/20 | 0.51 |
| ▸ | GHSR | Q92847 | 5/20 | 0.46 |
| ▸ | HTR2A | P28223 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6604795 | 1.00 | HTR1D (0.77) | HTR1DHTR1BHTR1AGHSRHTR2A | |
| SCHEMBL6603811 | 0.87 | HTR1D (1.00) | HTR1DHTR1BHTR1AGHSRHTR2A | |
| SCHEMBL6603817 | 0.87 | HTR1D (1.00) | HTR1DHTR1BHTR1AGHSRHTR2A | |
| SCHEMBL6101995 | 0.82 | HTR1D (0.84) | HTR1DHTR1BHTR1AGHSRHTR2A | |
| SCHEMBL6100097 | 0.81 | HTR1D (0.76) | HTR1DHTR1BHTR1AGHSRHTR2A | |
| SCHEMBL6603417 | 0.81 | HTR1D (1.00) | HTR1DHTR1BHTR1AHTR2AMAPT | |
| SCHEMBL6603418 | 0.81 | HTR1D (1.00) | HTR1DHTR1BHTR1AHTR2AMAPT | |
| SCHEMBL6100482 | 0.81 | HTR1D (0.78) | HTR1DHTR1BHTR1AHTR2AMAPT | |
| SCHEMBL6700971 | 0.78 | HTR1B (0.80) | HTR1DHTR1BHTR1AGHSR | |
| SCHEMBL6700974 | 0.78 | HTR1B (0.80) | HTR1DHTR1BHTR1AGHSR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1216239-B1 | PIPERAZINE DERIVATIVES AS 5-HT1B ANTAGONISTS | SMITHKLINE BEECHAM PLC (GB) | 2004-02-11 | — | — | EP | claimed |
| EP-1216239-B1 | PIPERAZINE DERIVATIVES AS 5-HT1B ANTAGONISTS | SMITHKLINE BEECHAM PLC (GB) | 2004-02-11 | — | — | EP | disclosed |