Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.69 |
| ▸ | MAPT | P10636 | 6/20 | 0.69 |
| ▸ | NPC1 | O15118 | 6/20 | 0.64 |
| ▸ | RAB9A | P51151 | 6/20 | 0.64 |
| ▸ | PPARG | P37231 | 2/20 | 0.64 |
| ▸ | NCOA2 | Q15596 | 2/20 | 0.64 |
| ▸ | NCOA1 | Q15788 | 2/20 | 0.64 |
| ▸ | NCOA3 | Q9Y6Q9 | 2/20 | 0.64 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.64 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.64 |
| ▸ | RELA | Q04206 | 1/20 | 0.64 |
| ▸ | HPGD | P15428 | 1/20 | 0.61 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.60 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.60 |
| ▸ | IKBKB | O14920 | 1/20 | 0.54 |
| ▸ | MEN1 | O00255 | 3/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.53 |
| ▸ | LMNA | P02545 | 1/20 | 0.53 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1193921 | 0.85 | SMN1; SMN2 (0.71) | SMN1; SMN2MAPTNPC1RAB9APPARG | |
| SCHEMBL608332 | 0.83 | SMN1; SMN2 (0.69) | SMN1; SMN2MAPTNPC1RAB9APPARG | |
| SCHEMBL892319 | 0.83 | SMN1; SMN2 (0.49) | SMN1; SMN2MAPTNPC1RAB9APPARG | |
| SCHEMBL31341150 | 0.83 | PTPN11 (0.58) | SMN1; SMN2MAPTNPC1RAB9APPARG | |
| SCHEMBL999672 | 0.83 | GSK3B (0.49) | SMN1; SMN2MAPTNPC1RAB9APPARG | |
| SCHEMBL892779 | 0.83 | MAPT (0.68) | SMN1; SMN2MAPTNPC1RAB9APPARG | |
| SCHEMBL12925920 | 0.83 | SMN1; SMN2 (0.49) | SMN1; SMN2MAPTNPC1RAB9APPARG | |
| SCHEMBL24187739 | 0.81 | NPC1 (0.74) | SMN1; SMN2MAPTNPC1RAB9APPARG | |
| SCHEMBL31341232 | 0.81 | NPC1 (0.74) | SMN1; SMN2MAPTNPC1RAB9APPARG | |
| SCHEMBL10848656 | 0.81 | CDC7 (0.61) | SMN1; SMN2MAPTNPC1RAB9APPARG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1102535-A4 | COMPOUNDS AND METHODS | SMITHKLINE BEECHAM CORP (US) | 2004-09-29 | — | — | EP | disclosed |
| EP-1102535-A2 | COMPOUNDS AND METHODS | SmithKline Beecham Corporation (US) | 2001-05-30 | — | — | EP | disclosed |
| WO-2000006085-A2 | COMPOUNDS AND METHODS | SMITHKLINE BEECHAM CORPORATION (US) | 2000-02-10 | — | — | WO | disclosed |