Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 8/20 | 0.69 |
| ▸ | MAPT | P10636 | 7/20 | 0.69 |
| ▸ | RAB9A | P51151 | 9/20 | 0.68 |
| ▸ | NPC1 | O15118 | 8/20 | 0.68 |
| ▸ | POLB | P06746 | 4/20 | 0.68 |
| ▸ | PPARG | P37231 | 2/20 | 0.64 |
| ▸ | NCOA2 | Q15596 | 2/20 | 0.64 |
| ▸ | NCOA1 | Q15788 | 2/20 | 0.64 |
| ▸ | NCOA3 | Q9Y6Q9 | 2/20 | 0.64 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.64 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.64 |
| ▸ | RELA | Q04206 | 1/20 | 0.64 |
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.62 |
| ▸ | HPGD | P15428 | 1/20 | 0.61 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.60 |
| ▸ | MEN1 | O00255 | 4/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.56 |
| ▸ | LMNA | P02545 | 1/20 | 0.56 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1193921 | 0.85 | SMN1; SMN2 (0.71) | SMN1; SMN2MAPTRAB9ANPC1POLB | |
| SCHEMBL14814199 | 0.83 | PTPN11 (0.58) | SMN1; SMN2MAPTRAB9ANPC1POLB | |
| SCHEMBL6604867 | 0.83 | SMN1; SMN2 (0.69) | SMN1; SMN2MAPTRAB9ANPC1POLB | |
| SCHEMBL850828 | 0.83 | NPC1 (0.68) | SMN1; SMN2MAPTRAB9ANPC1POLB | |
| SCHEMBL27807991 | 0.83 | MAPT (0.64) | SMN1; SMN2MAPTRAB9ANPC1POLB | |
| SCHEMBL13788324 | 0.81 | CDC7 (0.66) | SMN1; SMN2MAPTRAB9ANPC1POLB | |
| SCHEMBL12563592 | 0.80 | HDAC1 (0.52) | SMN1; SMN2MAPTRAB9ANPC1POLB | |
| SCHEMBL8345238 | 0.79 | CDC7 (0.75) | SMN1; SMN2MAPTRAB9ANPC1POLB | |
| SCHEMBL31301632 | 0.79 | SMN1; SMN2 (0.61) | SMN1; SMN2MAPTRAB9ANPC1POLB | |
| SCHEMBL23579076 | 0.78 | CDC7 (0.55) | SMN1; SMN2MAPTRAB9ANPC1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2188294-B1 | TRICYCLIC BRIDGED CYCLOPENTANEDIONE DERIVATIVES AS HERBICIDES | SYNGENTA LTD (GB) | 2015-03-18 | — | — | EP | disclosed |
| US-8956999-B2 | Herbicides | SYNGENTA LIMITED (GB) | 2015-02-17 | — | — | US | disclosed |
| EP-2176222-B1 | NOVEL HERBICIDES | SYNGENTA LTD (GB) | 2014-11-05 | — | — | EP | disclosed |
| US-8598365-B2 | Herbicides | SYNGENTA LIMITED (GB) | 2013-12-03 | — | — | US | disclosed |
| EP-2173727-B1 | NOVEL HERBICIDES | SYNGENTA LTD (GB) | 2013-11-06 | — | — | EP | disclosed |
| US-8541594-B2 | — | — | 2013-09-24 | — | — | US | disclosed |
| US-8530667-B2 | Herbicides | SYNGENTA LIMITED (GB) | 2013-09-10 | — | — | US | disclosed |
| US-20120040826-A1 | NOVEL HERBICIDES | SYNGENTA LIMITED (GB) | 2012-02-16 | — | — | US | disclosed |
| US-20100298140-A1 | NOVEL HERBICIDES | SYNGENTA LIMITED (GB) | 2010-11-25 | — | — | US | disclosed |
| US-20100279868-A1 | NOVEL HERBICIDES | SYNGENTA CROP PROTECTION, INC. (US) | 2010-11-04 | — | — | US | disclosed |
| EP-2188294-A2 | TRICYCLIC BRIDGED CYCLOPENTANEDIONE DERIVATIVES AS HERBICIDES | Syngenta Limited (GB) | 2010-05-26 | — | — | EP | disclosed |
| EP-2176222-A1 | NOVEL HERBICIDES | Syngenta Limited (GB) | 2010-04-21 | — | — | EP | disclosed |
| EP-2173727-A1 | NOVEL HERBICIDES | Syngenta Limited (GB) | 2010-04-14 | — | — | EP | disclosed |
| WO-2009030450-A2 | NOVEL HERBICIDES | SYNGENTA LIMITED (GB) | 2009-03-12 | — | — | WO | disclosed |
| WO-2009015877-A1 | NOVEL HERBICIDES | SYNGENTA LIMITED (GB) | 2009-02-05 | — | — | WO | disclosed |
| WO-2009000533-A1 | NOVEL HERBICIDES | SYNGENTA LIMITED (GB) | 2008-12-31 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120040826-A1 | NOVEL HERBICIDES | DDT, HDHD5, DDC | SMN1; SMN2 4358/4885MAPT 3907/4885RAB9A 3059/4885 |
| US-20100298140-A1 | NOVEL HERBICIDES | DDT, CYP1B1, CYP1A1 | SMN1; SMN2 2924/4885MAPT 3984/4885RAB9A 3091/4885 |
| US-20100279868-A1 | NOVEL HERBICIDES | DDT, HPD, HSD17B1 | SMN1; SMN2 4435/4885MAPT 3291/4885RAB9A 4207/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.