Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.55 |
| ▸ | HPGD | P15428 | 4/20 | 0.55 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.55 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.53 |
| ▸ | CDC25B | P30305 | 3/20 | 0.51 |
| ▸ | GPR35 | Q9HC97 | 2/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 2/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.45 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.44 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.44 |
| ▸ | NR4A3 | Q92570 | 1/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | GLA | P06280 | 1/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.44 |
| ▸ | ERN1 | O75460 | 1/20 | 0.44 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6604957 | 0.89 | KDM4E (0.54) | KDM4EALDH1A1HPGDNPSR1HSD17B10 | |
| SCHEMBL6234692 | 0.88 | KDM4E (0.73) | KDM4EALDH1A1HPGDNPSR1HSD17B10 | |
| SCHEMBL27377431 | 0.85 | GPR35 (0.47) | KDM4EALDH1A1HPGDNPSR1HSD17B10 | |
| SCHEMBL10584881 | 0.83 | KDM4E (0.77) | KDM4EALDH1A1HPGDNPSR1HSD17B10 | |
| SCHEMBL25295170 | 0.81 | HPGD (0.55) | KDM4EALDH1A1HPGDNPSR1HSD17B10 | |
| SCHEMBL3117234 | 0.81 | HPGD (0.55) | KDM4EALDH1A1HPGDNPSR1HSD17B10 | |
| SCHEMBL2780177 | 0.81 | KDM4E (0.58) | KDM4EALDH1A1HPGDNPSR1HSD17B10 | |
| SCHEMBL6441116 | 0.79 | GPR35 (0.65) | KDM4EALDH1A1HPGDNPSR1HSD17B10 | |
| Hydrochloric Acid SCHEMBL11588894 | 0.78 | GPR35 (0.63) | KDM4EALDH1A1HPGDNPSR1HSD17B10 | |
| SCHEMBL569680 | 0.78 | POLB (0.63) | KDM4EALDH1A1HPGDHSD17B10CDC25B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1119551-B1 | NAPHTHALENECARBOXAMIDES AS TACHYKININ RECEPTOR ANTAGONISTS | ASTRAZENECA AB (SE) | 2004-12-29 | — | — | EP | disclosed |
| EP-1433783-A2 | Naphthalenecarboxamides as tachykinin receptor antagonists | AstraZeneca AB (SE) | 2004-06-30 | — | — | EP | disclosed |
| EP-1119551-A1 | NAPHTHALENECARBOXAMIDES AS TACHYKININ RECEPTOR ANTAGONISTS | AstraZeneca AB (SE) | 2001-08-01 | — | — | EP | disclosed |
| WO-2000020389-A1 | NAPHTHALENECARBOXAMIDES AS TACHYKININ RECEPTOR ANTAGONISTS | ASTRAZENECA AB (SE) | 2000-04-13 | — | — | WO | disclosed |