Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPM8 | Q7Z2W7 | 2/20 | 0.39 |
| ▸ | CNR2 | P34972 | 1/20 | 0.38 |
| ▸ | FAAH | O00519 | 2/20 | 0.38 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.36 |
| ▸ | EPAS1 | Q99814 | 1/20 | 0.36 |
| ▸ | ALPL | P05186 | 5/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | PTGES | O14684 | 1/20 | 0.33 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | MMP1 | P03956 | 1/20 | 0.32 |
| ▸ | MMP9 | P14780 | 1/20 | 0.32 |
| ▸ | MMP13 | P45452 | 1/20 | 0.32 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.32 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.32 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.32 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6431116 | 1.00 | TRPM8 (0.39) | TRPM8CNR2FAAHHIF1AEPAS1 | |
| SCHEMBL6605211 | 1.00 | TRPM8 (0.39) | TRPM8CNR2FAAHHIF1AEPAS1 | |
| SCHEMBL6429249 | 0.96 | TRPM8 (0.37) | TRPM8CNR2FAAHHIF1AEPAS1 | |
| SCHEMBL6403790 | 0.95 | TRPM8 (0.36) | TRPM8CNR2FAAHHIF1AEPAS1 | |
| SCHEMBL6402948 | 0.93 | ACP1 (0.35) | TRPM8CNR2HIF1AEPAS1PTGES | |
| SCHEMBL6402952 | 0.93 | ACP1 (0.35) | TRPM8CNR2HIF1AEPAS1PTGES | |
| SCHEMBL6429732 | 0.93 | ACP1 (0.35) | TRPM8CNR2HIF1AEPAS1PTGES | |
| SCHEMBL6399629 | 0.86 | ADORA2A (0.31) | — | |
| SCHEMBL6604993 | 0.86 | MEN1 (0.31) | SMN1; SMN2KMT2AMEN1TP53 | |
| SCHEMBL6605583 | 0.85 | TRPM8 (0.40) | TRPM8CNR2FAAHHIF1AEPAS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1289980-B1 | BICYCLYL OR HETEROBICYCLYLMETHANESULFONYLAMINO-SUBSTITUTED N-HYDROXYFORMAMIDES | SMITHKLINE BEECHAM PLC (GB) | 2004-11-17 | — | — | EP | disclosed |