Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KEAP1 | Q14145 | 1/20 | 0.36 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.36 |
| ▸ | CYP11B1 | P15538 | 8/20 | 0.34 |
| ▸ | CYP11B2 | P19099 | 7/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6605291 | 1.00 | KEAP1 (0.36) | KEAP1NFE2L2CYP11B1CYP11B2 | |
| SCHEMBL9776053 | 0.94 | KEAP1 (0.35) | KEAP1NFE2L2CYP11B1CYP11B2 | |
| SCHEMBL9776049 | 0.94 | KEAP1 (0.35) | KEAP1NFE2L2CYP11B1CYP11B2 | |
| SCHEMBL7237684 | 0.85 | ATM (0.40) | CYP11B1CYP11B2 | |
| SCHEMBL7237682 | 0.85 | ATM (0.40) | CYP11B1CYP11B2 | |
| SCHEMBL5779276 | 0.84 | KEAP1 (0.54) | KEAP1NFE2L2CYP11B1CYP11B2 | |
| SCHEMBL22774579 | 0.84 | KEAP1 (0.54) | KEAP1NFE2L2CYP11B1CYP11B2 | |
| SCHEMBL5779272 | 0.84 | KEAP1 (0.54) | KEAP1NFE2L2CYP11B1CYP11B2 | |
| SCHEMBL6607388 | 0.83 | KEAP1 (0.35) | KEAP1NFE2L2CYP11B1CYP11B2 | |
| SCHEMBL6607390 | 0.83 | KEAP1 (0.35) | KEAP1NFE2L2CYP11B1CYP11B2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1140932-B1 | 1,8-BENZONAPHTHYRIDINE DERIVATIVES | AVENTIS PHARMA SA (FR) | 2004-03-17 | — | — | EP | disclosed |
| US-5556861-A | 1,8 benzonaphthyridine derivatives and antimicrobial compositions | LABORATOIRE ROGER BELLON (FR) | 1996-09-17 | — | — | US | disclosed |
| US-5053509-A | Microbiocides; AIDS | LABORATOIRE ROGER BELLON (FR) | 1991-10-01 | — | — | US | disclosed |
| US-5004745-A | Benzo[1,8]naphthyridine derivatives, their preparation and the compositions which contain them | LABORATOIRE ROGER BELLON (FR) | 1991-04-02 | — | — | US | disclosed |
| US-4990515-A | Chemical intermediates | RHONE-POULENC SANTE (FR) | 1991-02-05 | — | — | US | disclosed |
| US-4970213-A | Benzo(1,8)naphthyridine derivatives as intermediates | RHONE-POULENC SANTE (FR) | 1990-11-13 | — | — | US | disclosed |