Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.53 |
| ▸ | PPARA | Q07869 | 7/20 | 0.52 |
| ▸ | MCHR1 | Q99705 | 4/20 | 0.51 |
| ▸ | NPC1 | O15118 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.51 |
| ▸ | GAA | P10253 | 1/20 | 0.51 |
| ▸ | SCD | O00767 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 4/20 | 0.49 |
| ▸ | MEN1 | O00255 | 2/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.49 |
| ▸ | PPARG | P37231 | 3/20 | 0.46 |
| ▸ | PPARD | Q03181 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.45 |
| ▸ | MET | P08581 | 1/20 | 0.45 |
| ▸ | AHR | P35869 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6603843 | 0.94 | NR1H4 (0.54) | NR1H4PPARAMCHR1NPC1ALDH1A1 | |
| SCHEMBL6603157 | 0.92 | MAPT (0.53) | NR1H4PPARAMCHR1ALDH1A1SCD | |
| SCHEMBL6604870 | 0.90 | MAPT (0.52) | MCHR1ALDH1A1MAPTMEN1KMT2A | |
| SCHEMBL6602555 | 0.90 | MAPT (0.52) | MCHR1NPC1ALDH1A1GAAMAPT | |
| SCHEMBL6602810 | 0.89 | MCHR1 (0.54) | MCHR1NPC1ALDH1A1GAAMAPT | |
| SCHEMBL6605510 | 0.89 | MCHR1 (0.67) | NR1H4PPARAMCHR1NPC1ALDH1A1 | |
| SCHEMBL6604744 | 0.86 | MCHR1 (0.57) | NR1H4PPARAMCHR1NPC1ALDH1A1 | |
| SCHEMBL6604936 | 0.86 | MEN1 (0.53) | NR1H4PPARAMCHR1ALDH1A1SCD | |
| SCHEMBL6607030 | 0.85 | NR1H4 (0.62) | NR1H4PPARANPC1ALDH1A1GAA | |
| SCHEMBL7723576 | 0.84 | MAPT (0.53) | MCHR1ALDH1A1MAPTMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1102535-A4 | COMPOUNDS AND METHODS | SMITHKLINE BEECHAM CORP (US) | 2004-09-29 | — | — | EP | claimed |
| EP-1102535-A2 | COMPOUNDS AND METHODS | SmithKline Beecham Corporation (US) | 2001-05-30 | — | — | EP | claimed |
| WO-2000006085-A2 | COMPOUNDS AND METHODS | SMITHKLINE BEECHAM CORPORATION (US) | 2000-02-10 | — | — | WO | claimed |
| EP-1102535-A4 | COMPOUNDS AND METHODS | SMITHKLINE BEECHAM CORP (US) | 2004-09-29 | — | — | EP | disclosed |
| EP-1102535-A2 | COMPOUNDS AND METHODS | SmithKline Beecham Corporation (US) | 2001-05-30 | — | — | EP | disclosed |
| WO-2000006085-A2 | COMPOUNDS AND METHODS | SMITHKLINE BEECHAM CORPORATION (US) | 2000-02-10 | — | — | WO | disclosed |