Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MCHR1 | Q99705 | 11/20 | 0.67 |
| ▸ | HTR2C | P28335 | 1/20 | 0.53 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.53 |
| ▸ | PPARA | Q07869 | 5/20 | 0.52 |
| ▸ | NPC1 | O15118 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.51 |
| ▸ | GAA | P10253 | 1/20 | 0.51 |
| ▸ | SCD | O00767 | 1/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
| ▸ | PPARG | P37231 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6604744 | 0.92 | MCHR1 (0.57) | MCHR1HTR2CNR1H4PPARANPC1 | |
| SCHEMBL6603148 | 0.92 | MCHR1 (0.65) | MCHR1HTR2CNR1H4PPARAALDH1A1 | |
| SCHEMBL6604858 | 0.90 | MCHR1 (0.53) | MCHR1HTR2CMAPT | |
| SCHEMBL6603843 | 0.90 | NR1H4 (0.54) | MCHR1NR1H4PPARANPC1ALDH1A1 | |
| SCHEMBL6602551 | 0.90 | MCHR1 (0.54) | MCHR1HTR2CGAAMEN1MAPT | |
| SCHEMBL6602805 | 0.89 | MCHR1 (0.62) | MCHR1HTR2CMEN1KMT2A | |
| SCHEMBL6605515 | 0.89 | NR1H4 (0.53) | MCHR1NR1H4PPARANPC1ALDH1A1 | |
| SCHEMBL6607020 | 0.85 | NR1H4 (0.62) | MCHR1NR1H4PPARANPC1ALDH1A1 | |
| SCHEMBL7728765 | 0.82 | KDM4E (0.57) | MCHR1HTR2CNPC1ALDH1A1GAA | |
| SCHEMBL6603515 | 0.82 | MCHR1 (0.49) | MCHR1HTR2CALDH1A1MEN1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1102535-A4 | COMPOUNDS AND METHODS | SMITHKLINE BEECHAM CORP (US) | 2004-09-29 | — | — | EP | claimed |
| EP-1102535-A2 | COMPOUNDS AND METHODS | SmithKline Beecham Corporation (US) | 2001-05-30 | — | — | EP | claimed |
| WO-2000006085-A2 | COMPOUNDS AND METHODS | SMITHKLINE BEECHAM CORPORATION (US) | 2000-02-10 | — | — | WO | claimed |
| EP-1102535-A4 | COMPOUNDS AND METHODS | SMITHKLINE BEECHAM CORP (US) | 2004-09-29 | — | — | EP | disclosed |
| US-6399656-B1 | USING A BENZOPYRAN-3-CARBOXAMIDE COMPOUND | SMITHKLINE BEECHAM CORPORATION | 2002-06-04 | — | — | US | disclosed |
| EP-1102535-A2 | COMPOUNDS AND METHODS | SmithKline Beecham Corporation (US) | 2001-05-30 | — | — | EP | disclosed |
| WO-2000006085-A2 | COMPOUNDS AND METHODS | SMITHKLINE BEECHAM CORPORATION (US) | 2000-02-10 | — | — | WO | disclosed |