Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 10/20 | 0.50 |
| ▸ | PDE4B | Q07343 | 10/20 | 0.50 |
| ▸ | PDE4C | Q08493 | 10/20 | 0.50 |
| ▸ | PDE4D | Q08499 | 10/20 | 0.50 |
| ▸ | PDGFRB | P09619 | 2/20 | 0.41 |
| ▸ | PDGFRA | P16234 | 2/20 | 0.41 |
| ▸ | SCN9A | Q15858 | 4/20 | 0.39 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.36 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.36 |
| ▸ | BRS3 | P32247 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6609815 | 0.84 | PDE4A (0.46) | PDE4APDE4BPDE4CPDE4DPDGFRB | |
| SCHEMBL6608573 | 0.84 | PDE4A (0.48) | PDE4APDE4BPDE4CPDE4DPDGFRB | |
| SCHEMBL6609416 | 0.83 | PDE4B (0.45) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL6609414 | 0.83 | PDE4B (0.45) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL6610689 | 0.83 | CHEK1 (0.36) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL6605787 | 0.79 | CNR2 (0.43) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL6605781 | 0.79 | CNR2 (0.43) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL6609471 | 0.79 | PDE4D (0.41) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL6609466 | 0.79 | PDE4D (0.41) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL6612839 | 0.78 | PDE4B (0.41) | PDE4APDE4BPDE4CPDE4D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0882714-B1 | SUBSTITUTED VINYLPYRIDINE DERIVATIVES AND DRUGS CONTAINING THE SAME | SS PHARMACEUTICAL CO (JP) | 2004-03-03 | — | — | EP | disclosed |
| EP-0882714-A1 | SUBSTITUTED VINYLPYRIDINE DERIVATIVES AND DRUGS CONTAINING THE SAME | SS Pharmaceutical Co., Ltd. (JP) | 1998-12-09 | — | — | EP | disclosed |