SCHEMBL6605852

SCHEMBL6605852

Cc1cccc(CC2=C(O)CC(c3ccccc3)(c3ccccc3)OC2=O)c1

nearest known ligand 0.41

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
LDHA P00338 4/20 0.41
LDHB P07195 4/20 0.41
LMNA P02545 1/20 0.39
NPSR1 Q6W5P4 1/20 0.39
NR3C1 P04150 2/20 0.37
DAO P14920 2/20 0.36
HCAR2 Q8TDS4 1/20 0.36
HSD11B1 P28845 1/20 0.36
CHRM2 P08172 1/20 0.35
CHRM3 P20309 1/20 0.35
ALDH1A1 P00352 2/20 0.35
XIAP P98170 1/20 0.35
KDM4E B2RXH2 1/20 0.35
CYP3A4 P08684 1/20 0.35
RECQL P46063 1/20 0.35
TDP1 Q9NUW8 1/20 0.35
MAOB P27338 1/20 0.35
KMT2A Q03164 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6604456 0.87 LDHA (0.48) LDHALDHBCHRM2CHRM3ALDH1A1
SCHEMBL9048781 0.86 LDHA (0.38) LDHALDHBLMNANPSR1DAO
SCHEMBL7437581 0.85 LDHA (0.44) LDHALDHBCHRM2CHRM3
SCHEMBL6604662 0.80 LDHA (0.36) LDHALMNANPSR1NR3C1DAO
SCHEMBL6606237 0.79 LDHA (0.43) LDHALDHBALDH1A1
SCHEMBL6606184 0.76 LDHA (0.45) LDHALDHBLMNAXIAPRECQL
SCHEMBL6604881 0.74 LDHA (0.36) LDHALDHB
SCHEMBL6605274 0.74 LDHA (0.42) LDHALDHBTDP1KMT2A
SCHEMBL6609876 0.73 LDHA (0.55) LDHALDHB
SCHEMBL6603648 0.73 LDHA (0.41) LDHALDHBHCAR2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1142887-B1 5,6-dihydropyrone derivatives as protease inhibitors and antiviral agents PARKE DAVIS & CO (US) 2004-04-07 EP disclosed
EP-1142887-A1 5,6-dihydropyrone derivatives as protease inhibitors and antiviral agents PARKE, DAVIS & COMPANY (US) 2001-10-10 EP disclosed
US-5936128-A BENZENETHIOL COMPOUNDS AS INTERMEDIATES; BACTERICIDES, VIRICIDES; HIV WARNER-LAMBERT COMPANY (US) 1999-08-10 US disclosed
US-5840751-A ADMINISTERING IN THE TREATMENT OF INFECTION OR DISEASE CAUSED BY A RETROVIRUS WARNER-LAMBERT COMPANY (US) 1998-11-24 US disclosed
US-5789440-A 5,6-dihydropyrone derivatives as protease inhibitors and antiviral agents WARNER-LAMBERT COMPANY (US) 1998-08-04 US disclosed
EP-0729463-A1 5,6-DIHYDROPYRONE DERIVATIVES AS PROTEASE INHIBITORS AND ANTIVIRAL AGENTS PARKE DAVIS & COMPANY (US) 1996-09-04 EP disclosed
EP-0729464-A1 5,6-DIHYDROPYRONE DERIVATIVES AS PROTEASE INHIBITORS AND ANTIVIRAL AGENTS PARKE, DAVIS & COMPANY (US) 1996-09-04 EP disclosed
WO-1995014012-A1 5,6-DIHYDROPYRONE DERIVATIVES AS PROTEASE INHIBITORS AND ANTIVIRAL AGENTS PARKE, DAVIS & COMPANY (US) 1995-05-26 WO disclosed
WO-1995014011-A2 5,6-DIHYDROPYRONE DERIVATIVES AS PROTEASE INHIBITORS AND ANTIVIRAL AGENTS PARKE, DAVIS & COMPANY (US) 1995-05-26 WO disclosed