⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8671567 | 0.87 | MMP8 (0.46) | — | |
| SCHEMBL4526544 | 0.78 | — | — | |
| SCHEMBL8284899 | 0.78 | — | — | |
| SCHEMBL1365530 | 0.78 | — | — | |
| SCHEMBL5542040 | 0.78 | — | — | |
| Hydrochloric Acid SCHEMBL2206774 | 0.76 | TAAR1 (0.40) | — | |
| SCHEMBL22558665 | 0.75 | MMP8 (0.42) | — | |
| SCHEMBL5543296 | 0.75 | MMP8 (0.39) | — | |
| SCHEMBL16564263 | 0.73 | TAAR1 (0.41) | — | |
| SCHEMBL16414421 | 0.73 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110225911-B | Oxadiazolone transient receptor potential channel inhibitors | 豪夫迈·罗氏有限公司 | 2022-04-05 | — | — | CN | disclosed |
| EP-3544979-B1 | OXADIAZOLONES AS TRANSIENT RECEPTOR POTENTIAL CHANNEL INHIBITORS | HOFFMANN LA ROCHE (CH) | 2021-08-04 | — | — | EP | disclosed |
| US-10913742-B2 | Oxadiazolones as transient receptor potential channel inhibitors | GENENTECH, INC. (US) | 2021-02-09 | — | — | US | disclosed |
| EP-3544979-A1 | OXADIAZOLONES AS TRANSIENT RECEPTOR POTENTIAL CHANNEL INHIBITORS | H. Hoffnabb-La Roche Ag (CH) | 2019-10-02 | — | — | EP | disclosed |
| US-20190284189-A1 | OXADIAZOLONES AS TRANSIENT RECEPTOR POTENTIAL CHANNEL INHIBITORS | GENENTECH, INC. (US) | 2019-09-19 | — | — | US | disclosed |
| WO-2018096159-A1 | OXADIAZOLONES AS TRANSIENT RECEPTOR POTENTIAL CHANNEL INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2018-05-31 | — | — | WO | disclosed |
| CN-1170819-C | Piperidine alcohols | Ĭ��ר���ɷ�����˾ | 2004-10-13 | — | — | CN | disclosed |
| US-6756370-B1 | POTENT 5-HT2A RECEPTOR ANTAGONISTS | MERCK PATENT GMBH (DE) | 2004-06-29 | — | — | US | disclosed |
| EP-1202966-B1 | PIPERIDINE ALCOHOLS | MERCK PATENT GMBH (DE) | 2004-06-09 | — | — | EP | disclosed |
| CN-1371365-A | Piperidine alcohols | MERCK PATENT GMBH (DE) | 2002-09-25 | — | — | CN | disclosed |
| EP-1202966-A1 | PIPERIDINE ALCOHOLS | MERCK PATENT GmbH (DE) | 2002-05-08 | — | — | EP | disclosed |
| WO-2001014332-A1 | PIPERIDINE ALCOHOLS | MERCK PATENT GMBH (DE) | 2001-03-01 | — | — | WO | disclosed |