Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCNE2 | O96020 | 2/20 | 0.47 |
| ▸ | CCNE1 | P24864 | 2/20 | 0.47 |
| ▸ | CDK2 | P24941 | 2/20 | 0.47 |
| ▸ | GSK3B | P49841 | 2/20 | 0.47 |
| ▸ | TBK1 | Q9UHD2 | 13/20 | 0.47 |
| ▸ | IKBKE | Q14164 | 12/20 | 0.47 |
| ▸ | PIM2 | Q9P1W9 | 2/20 | 0.40 |
| ▸ | PIM1 | P11309 | 1/20 | 0.40 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.40 |
| ▸ | ATR | Q13535 | 1/20 | 0.40 |
| ▸ | PRKCI | P41743 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6033879 | 0.96 | TBK1 (0.50) | CCNE2CCNE1CDK2GSK3BTBK1 | |
| SCHEMBL6035019 | 0.79 | GSK3B (0.61) | CCNE2CCNE1CDK2GSK3BTBK1 | |
| SCHEMBL6035809 | 0.74 | CACNA1B (0.46) | CCNE2CCNE1CDK2GSK3BTBK1 | |
| SCHEMBL6033839 | 0.74 | GSK3B (0.74) | CCNE2CCNE1CDK2GSK3BTBK1 | |
| Hydrochloric Acid SCHEMBL6036000 | 0.73 | GSK3B (0.73) | CCNE2CCNE1CDK2GSK3BTBK1 | |
| SCHEMBL14059578 | 0.72 | TBK1 (0.58) | TBK1IKBKEATRPRKCI | |
| SCHEMBL14059044 | 0.72 | IKBKE (0.55) | TBK1IKBKEPRKCI | |
| SCHEMBL6034173 | 0.70 | GSK3B (0.53) | CCNE2CCNE1CDK2GSK3BTBK1 | |
| SCHEMBL14059394 | 0.70 | PRKCI (0.66) | TBK1IKBKEPRKCIGAA | |
| SCHEMBL3146262 | 0.69 | PHF13 (0.50) | ATR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1414801-A1 | ARYLAMINES FOR THE TREATMENT OF CONDITIONS ASSOCIATED WITH GSK-3 | AstraZeneca AB (SE) | 2004-05-06 | — | — | EP | disclosed |
| WO-2003004472-A1 | ARYLAMINES FOR THE TREATMENT OF CONDITIONS ASSOCIATED WITH GSK-3 | ASTRAZENECA AB (SE) | 2003-01-16 | — | — | WO | disclosed |