Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.67 |
| ▸ | KDR | P35968 | 7/20 | 0.61 |
| ▸ | ROCK2 | O75116 | 11/20 | 0.57 |
| ▸ | ROCK1 | Q13464 | 4/20 | 0.57 |
| ▸ | IGF1R | P08069 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26715276 | 0.83 | MAPKAPK2 (0.71) | MAPKAPK2KDRROCK2ROCK1IGF1R | |
| SCHEMBL3459554 | 0.80 | MAPKAPK2 (0.71) | MAPKAPK2KDRROCK2ROCK1IGF1R | |
| SCHEMBL20783989 | 0.80 | MAPKAPK2 (1.00) | MAPKAPK2KDRROCK2ROCK1IGF1R | |
| SCHEMBL26717703 | 0.80 | MAPKAPK2 (0.67) | MAPKAPK2KDRROCK2ROCK1IGF1R | |
| SCHEMBL18114560 | 0.76 | ROCK2 (0.71) | MAPKAPK2KDRROCK2ROCK1 | |
| SCHEMBL3810286 | 0.76 | MAPKAPK2 (0.65) | MAPKAPK2KDRROCK2ROCK1IGF1R | |
| SCHEMBL4879499 | 0.75 | KDR (0.71) | MAPKAPK2KDRROCK2ROCK1IGF1R | |
| SCHEMBL18114550 | 0.75 | ROCK2 (0.61) | MAPKAPK2KDRROCK2ROCK1 | |
| SCHEMBL18792311 | 0.75 | ROCK2 (0.75) | ROCK2ROCK1 | |
| SCHEMBL18114563 | 0.74 | KDR (0.66) | MAPKAPK2KDRROCK2ROCK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1235806-A4 | NOVEL 5-PYRIMIDINECARBOXAMIDE DERIVATIVES AND THE PHARMACEUTICAL COMPOSITIONS CONTAINING SAID DERIVATIVES | DONG WHA PHARM IND CO LTD (KR) | 2004-02-04 | — | — | EP | disclosed |
| EP-1235806-A1 | NOVEL 5-PYRIMIDINECARBOXAMIDE DERIVATIVES AND THE PHARMACEUTICAL COMPOSITIONS CONTAINING SAID DERIVATIVES | DONG WHA PHARMACEUTICAL INDUSTRIAL CO. LTD. (KR) | 2002-09-04 | — | — | EP | disclosed |
| WO-2001038308-A1 | NOVEL 5-PYRIMIDINECARBOXAMIDE DERIVATIVES AND THE PHARMACEUTICAL COMPOSITIONS CONTAINING SAID DERIVATIVES | DONG WHA PHARM. IND. CO., LTD (KR) | 2001-05-31 | — | — | WO | disclosed |