SCHEMBL6606214

SCHEMBL6606214

COc1ccccc1CSC1=C(O)CC(CCC(C)C)(c2ccccc2)OC1=O

nearest known ligand 0.43

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
LDHA P00338 9/20 0.43
LDHB P07195 1/20 0.35
HSD11B1 P28845 1/20 0.35
CTSB P07858 1/20 0.34
PTGDR2 Q9Y5Y4 1/20 0.34
HPGD P15428 2/20 0.33
HTT P42858 1/20 0.33
NR3C2 P08235 1/20 0.33
UTS2R Q9UKP6 1/20 0.33
GRIN2B Q13224 1/20 0.33
MEN1 O00255 3/20 0.33
KMT2A Q03164 3/20 0.33
MAPT P10636 2/20 0.33
CYP3A4 P08684 1/20 0.33
TSHR P16473 1/20 0.33
TACR1 P25103 1/20 0.33
CYP2C19 P33261 1/20 0.33
PTK2 Q05397 1/20 0.32
ALDH1A1 P00352 1/20 0.32
MAPK1 P28482 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6607008 0.86 LDHA (0.54) LDHALDHB
SCHEMBL6608866 0.84 LDHA (0.48) LDHALDHBHPGD
SCHEMBL6604999 0.83 LDHA (0.42) LDHALDHB
SCHEMBL6607582 0.82 LDHA (0.42) LDHALDHBHTTMEN1KMT2A
SCHEMBL6608000 0.80 LDHA (0.53) LDHALDHBALDH1A1
SCHEMBL6610895 0.79 LDHA (0.47) LDHALDHBHPGDTSHRALDH1A1
SCHEMBL6607615 0.79 LDHA (0.44) LDHALDHBHSD11B1HPGDCYP3A4
SCHEMBL6607921 0.78 LDHA (0.43) LDHALDHBPTGDR2TSHR
SCHEMBL6606212 0.78 LDHA (0.44) LDHALDHBHSD11B1UTS2R
SCHEMBL6608692 0.77 LDHA (0.47) LDHALDHBHSD11B1CYP3A4CYP2C19

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1142887-B1 5,6-dihydropyrone derivatives as protease inhibitors and antiviral agents PARKE DAVIS & CO (US) 2004-04-07 EP disclosed
EP-0729463-B1 5,6-DIHYDROPYRONE DERIVATIVES AS PROTEASE INHIBITORS AND ANTIVIRAL AGENTS PARKE DAVIS & CO (US) 2002-05-22 EP disclosed
EP-1142887-A1 5,6-dihydropyrone derivatives as protease inhibitors and antiviral agents PARKE, DAVIS & COMPANY (US) 2001-10-10 EP disclosed
US-5936128-A BENZENETHIOL COMPOUNDS AS INTERMEDIATES; BACTERICIDES, VIRICIDES; HIV WARNER-LAMBERT COMPANY (US) 1999-08-10 US disclosed
US-5840751-A ADMINISTERING IN THE TREATMENT OF INFECTION OR DISEASE CAUSED BY A RETROVIRUS WARNER-LAMBERT COMPANY (US) 1998-11-24 US disclosed
US-5789440-A 5,6-dihydropyrone derivatives as protease inhibitors and antiviral agents WARNER-LAMBERT COMPANY (US) 1998-08-04 US disclosed
EP-0729463-A1 5,6-DIHYDROPYRONE DERIVATIVES AS PROTEASE INHIBITORS AND ANTIVIRAL AGENTS PARKE DAVIS & COMPANY (US) 1996-09-04 EP disclosed
EP-0729464-A1 5,6-DIHYDROPYRONE DERIVATIVES AS PROTEASE INHIBITORS AND ANTIVIRAL AGENTS PARKE, DAVIS & COMPANY (US) 1996-09-04 EP disclosed
WO-1995014012-A1 5,6-DIHYDROPYRONE DERIVATIVES AS PROTEASE INHIBITORS AND ANTIVIRAL AGENTS PARKE, DAVIS & COMPANY (US) 1995-05-26 WO disclosed
WO-1995014011-A2 5,6-DIHYDROPYRONE DERIVATIVES AS PROTEASE INHIBITORS AND ANTIVIRAL AGENTS PARKE, DAVIS & COMPANY (US) 1995-05-26 WO disclosed