Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 1/20 | 0.40 |
| ▸ | BRD2 | P25440 | 1/20 | 0.40 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 4/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | CA12 | O43570 | 1/20 | 0.33 |
| ▸ | CA1 | P00915 | 1/20 | 0.33 |
| ▸ | CA2 | P00918 | 1/20 | 0.33 |
| ▸ | CA3 | P07451 | 1/20 | 0.33 |
| ▸ | CA4 | P22748 | 1/20 | 0.33 |
| ▸ | CA6 | P23280 | 1/20 | 0.33 |
| ▸ | CA5A | P35218 | 1/20 | 0.33 |
| ▸ | CA7 | P43166 | 1/20 | 0.33 |
| ▸ | CA9 | Q16790 | 1/20 | 0.33 |
| ▸ | CA13 | Q8N1Q1 | 1/20 | 0.33 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.33 |
| ▸ | CA5B | Q9Y2D0 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 2/20 | 0.32 |
| ▸ | CHRM2 | P08172 | 3/20 | 0.32 |
| ▸ | CHRM5 | P08912 | 3/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6608794 | 0.85 | BRD4 (0.38) | BRD4BRD2PIK3CDLMNAKMT2A | |
| SCHEMBL10093754 | 0.82 | BRD4 (0.41) | BRD4BRD2PIK3CDLMNAKMT2A | |
| SCHEMBL21465976 | 0.80 | BRD4 (0.40) | BRD4BRD2PIK3CDLMNAKMT2A | |
| SCHEMBL4508963 | 0.80 | BRD4 (0.40) | BRD4BRD2PIK3CDLMNAKMT2A | |
| SCHEMBL11028251 | 0.80 | BRD4 (0.40) | BRD4BRD2PIK3CDLMNAKMT2A | |
| SCHEMBL7620731 | 0.79 | BRD4 (0.36) | BRD4BRD2PIK3CDLMNAKMT2A | |
| SCHEMBL19918791 | 0.78 | BRD4 (0.39) | BRD4BRD2PIK3CDLMNAKMT2A | |
| SCHEMBL25988587 | 0.78 | BRD4 (0.39) | BRD4BRD2PIK3CDLMNAKMT2A | |
| SCHEMBL19106731 | 0.77 | PIK3CD (0.47) | BRD4BRD2PIK3CDLMNAKMT2A | |
| SCHEMBL22080929 | 0.77 | BRD4 (0.34) | BRD4BRD2PIK3CDLMNATSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1106614-B1 | 5-Membered heteroaryl substituted 1,4-dihydropyridine compounds as bradykinin antagonists | PFIZER (US) | 2004-01-07 | — | — | EP | disclosed |
| US-6444677-B2 | TREATMENT OF INFLAMMATION, CARDIOVASCULAR DISEASE, PAIN, ETC. | PFIZER INC. | 2002-09-03 | — | — | US | disclosed |
| EP-1106614-A1 | 5-Membered heteroaryl substituted 1,4-dihydropyridine compounds as bradykinin antagonists | PFIZER INC. (US) | 2001-06-13 | — | — | EP | disclosed |