Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK2 | P24941 | 9/20 | 0.44 |
| ▸ | IKBKB | O14920 | 5/20 | 0.43 |
| ▸ | CDK4 | P11802 | 3/20 | 0.43 |
| ▸ | STK4 | Q13043 | 2/20 | 0.43 |
| ▸ | CNR1 | P21554 | 2/20 | 0.42 |
| ▸ | CNR2 | P34972 | 2/20 | 0.42 |
| ▸ | CCNT1 | O60563 | 2/20 | 0.40 |
| ▸ | CDK9 | P50750 | 2/20 | 0.40 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.40 |
| ▸ | DKK1 | O94907 | 1/20 | 0.40 |
| ▸ | GSK3B | P49841 | 1/20 | 0.40 |
| ▸ | CDK1 | P06493 | 1/20 | 0.40 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.40 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.40 |
| ▸ | CDK7 | P50613 | 1/20 | 0.40 |
| ▸ | CCNH | P51946 | 1/20 | 0.40 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6604316 | 0.87 | CDK2 (0.50) | CDK2CDK4CCNA2CCNA1 | |
| SCHEMBL6607780 | 0.87 | CDK2 (0.41) | CDK2IKBKBCDK4STK4CCNT1 | |
| SCHEMBL6604517 | 0.86 | CDK2 (0.44) | CDK2IKBKBCDK4STK4CNR1 | |
| SCHEMBL6603610 | 0.85 | SYK (0.44) | CDK2IKBKBCDK4CCNT1CDK9 | |
| SCHEMBL6606019 | 0.84 | CDK2 (0.64) | CDK2IKBKBCDK4CDK1 | |
| SCHEMBL5095478 | 0.76 | CDK2 (0.56) | CDK2CDK4STK4CCNT1CDK9 | |
| SCHEMBL6103961 | 0.76 | CDK2 (0.72) | CDK2CDK4CCNT1CDK9GSK3B | |
| SCHEMBL6604567 | 0.76 | CDK2 (0.64) | CDK2IKBKBCDK4CDK1 | |
| SCHEMBL6606156 | 0.76 | CDK2 (0.52) | CDK2IKBKBCDK4CCNT1CDK9 | |
| SCHEMBL6104318 | 0.76 | CDK2 (0.71) | CDK2CDK4STK4CCNT1CDK9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1490354-A1 | 4-IMIDAZOLYL SUBSTITUTED PYRIMIDINE DERIVATIVES WITH CDK INHIBITORY ACTIVITY | Astrazeneca AB (SE) | 2004-12-29 | — | — | EP | claimed |
| WO-2003076434-A1 | 4- IMIDAZOLYL SUBSTUITED PYRIMIDINE DERIVATIVES WITH CDK INHIBITIORY ACTIVITY | ASTRAZENECA AB (SE) | 2003-09-18 | — | — | WO | claimed |
| EP-1490354-A1 | 4-IMIDAZOLYL SUBSTITUTED PYRIMIDINE DERIVATIVES WITH CDK INHIBITORY ACTIVITY | Astrazeneca AB (SE) | 2004-12-29 | — | — | EP | disclosed |
| WO-2003076434-A1 | 4- IMIDAZOLYL SUBSTUITED PYRIMIDINE DERIVATIVES WITH CDK INHIBITIORY ACTIVITY | ASTRAZENECA AB (SE) | 2003-09-18 | — | — | WO | disclosed |