Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LCK | P06239 | 13/20 | 0.68 |
| ▸ | ABL1 | P00519 | 9/20 | 0.68 |
| ▸ | SRC | P12931 | 6/20 | 0.68 |
| ▸ | BCR | P11274 | 5/20 | 0.68 |
| ▸ | EGFR | P00533 | 3/20 | 0.68 |
| ▸ | FYN | P06241 | 3/20 | 0.68 |
| ▸ | YES1 | P07947 | 3/20 | 0.68 |
| ▸ | LYN | P07948 | 3/20 | 0.68 |
| ▸ | HCK | P08631 | 3/20 | 0.68 |
| ▸ | KIT | P10721 | 3/20 | 0.68 |
| ▸ | MAPK14 | Q16539 | 3/20 | 0.68 |
| ▸ | MAPK13 | O15264 | 2/20 | 0.68 |
| ▸ | ERBB2 | P04626 | 2/20 | 0.68 |
| ▸ | FGR | P09769 | 2/20 | 0.68 |
| ▸ | JAK3 | P52333 | 2/20 | 0.68 |
| ▸ | MAPK12 | P53778 | 2/20 | 0.68 |
| ▸ | MAPK11 | Q15759 | 2/20 | 0.68 |
| ▸ | SIK1 | P57059 | 3/20 | 0.51 |
| ▸ | SIK2 | Q9H0K1 | 3/20 | 0.51 |
| ▸ | SIK3 | Q9Y2K2 | 3/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20633186 | 0.86 | LCK (0.86) | LCKABL1SRCBCREGFR | |
| SCHEMBL774475 | 0.82 | LCK (0.71) | LCKABL1SRCBCREGFR | |
| SCHEMBL31060141 | 0.81 | LCK (1.00) | LCKABL1SRCBCREGFR | |
| SCHEMBL774220 | 0.81 | LCK (1.00) | LCKABL1SRCBCREGFR | |
| SCHEMBL15101028 | 0.81 | LCK (0.63) | LCKABL1SRCBCREGFR | |
| SCHEMBL27768520 | 0.80 | LCK (0.61) | LCKABL1SRCBCREGFR | |
| SCHEMBL774309 | 0.80 | LCK (1.00) | LCKABL1SRCBCREGFR | |
| SCHEMBL774835 | 0.80 | LCK (0.69) | LCKABL1SRCBCREGFR | |
| SCHEMBL24686329 | 0.79 | LCK (0.77) | LCKABL1SRCBCREGFR | |
| SCHEMBL774847 | 0.79 | LCK (0.71) | LCKABL1SRCBCREGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1169038-A4 | CYCLIC PROTEIN TYROSINE KINASE INHIBITORS | BRISTOL MYERS SQUIBB CO (US) | 2004-10-13 | — | — | EP | claimed |
| EP-1169038-A1 | CYCLIC PROTEIN TYROSINE KINASE INHIBITORS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2002-01-09 | — | — | EP | claimed |
| WO-2000062778-A1 | CYCLIC PROTEIN TYROSINE KINASE INHIBITORS | BRISTOL-MYERS SQUIBB CO. (US) | 2000-10-26 | — | — | WO | claimed |