Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LCK | P06239 | 9/20 | 0.61 |
| ▸ | ABL1 | P00519 | 10/20 | 0.60 |
| ▸ | BCR | P11274 | 5/20 | 0.60 |
| ▸ | SRC | P12931 | 3/20 | 0.60 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.60 |
| ▸ | EGFR | P00533 | 1/20 | 0.60 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.60 |
| ▸ | FYN | P06241 | 1/20 | 0.60 |
| ▸ | YES1 | P07947 | 1/20 | 0.60 |
| ▸ | LYN | P07948 | 1/20 | 0.60 |
| ▸ | HCK | P08631 | 1/20 | 0.60 |
| ▸ | FGR | P09769 | 1/20 | 0.60 |
| ▸ | KIT | P10721 | 1/20 | 0.60 |
| ▸ | JAK3 | P52333 | 1/20 | 0.60 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.60 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.60 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.60 |
| ▸ | HDAC1 | Q13547 | 4/20 | 0.56 |
| ▸ | PKMYT1 | Q99640 | 1/20 | 0.52 |
| ▸ | SIK1 | P57059 | 3/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL774847 | 0.87 | LCK (0.71) | LCKABL1BCRSRCMAPK13 | |
| SCHEMBL27747455 | 0.85 | ABL1 (0.46) | LCKABL1BCRSRCMAPK13 | |
| SCHEMBL774835 | 0.82 | LCK (0.69) | LCKABL1BCRSRCMAPK13 | |
| SCHEMBL6606724 | 0.80 | LCK (0.68) | LCKABL1BCRSRCMAPK13 | |
| SCHEMBL20633186 | 0.79 | LCK (0.86) | LCKABL1BCRSRCMAPK13 | |
| SCHEMBL27747454 | 0.79 | ABL1 (0.41) | LCKABL1BCRSRCMAPK13 | |
| SCHEMBL27818091 | 0.77 | LCK (0.67) | LCKABL1BCRSRCMAPK13 | |
| SCHEMBL28371011 | 0.77 | LCK (0.63) | LCKABL1BCRSRCMAPK13 | |
| SCHEMBL20785959 | 0.77 | PKMYT1 (0.66) | LCKABL1BCRSRCMAPK13 | |
| SCHEMBL774475 | 0.76 | LCK (0.71) | LCKABL1BCRSRCMAPK13 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101481359-A | Cyclic protein tyrosine kinase inhibitors | BRISTOL MYERS SQUIBB CO (US) | 2009-07-15 | — | — | CN | claimed |