Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADAM17 | P78536 | 19/20 | 0.57 |
| ▸ | MMP13 | P45452 | 1/20 | 0.56 |
| ▸ | ADAMTS4 | O75173 | 2/20 | 0.52 |
| ▸ | MMP3 | P08254 | 2/20 | 0.52 |
| ▸ | MMP7 | P09237 | 2/20 | 0.52 |
| ▸ | ADAMTS1 | Q9UHI8 | 2/20 | 0.52 |
| ▸ | ADAMTS5 | Q9UNA0 | 2/20 | 0.52 |
| ▸ | MMP8 | P22894 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6597679 | 0.88 | ADAM17 (0.75) | ADAM17MMP13ADAMTS4MMP3MMP7 | |
| SCHEMBL6598893 | 0.80 | ADAM17 (0.76) | ADAM17MMP13 | |
| SCHEMBL6594529 | 0.78 | ADAM17 (0.58) | ADAM17 | |
| SCHEMBL6596696 | 0.76 | ADAM17 (0.83) | ADAM17MMP13ADAMTS4MMP3MMP7 | |
| SCHEMBL6598016 | 0.76 | ADAM17 (0.80) | ADAM17MMP13ADAMTS4MMP3MMP7 | |
| SCHEMBL6598436 | 0.76 | ADAM17 (0.56) | ADAM17 | |
| SCHEMBL6596146 | 0.74 | ADAM17 (0.78) | ADAM17MMP13ADAMTS4MMP3MMP7 | |
| SCHEMBL6595238 | 0.73 | ADAM17 (0.56) | ADAM17 | |
| SCHEMBL6365154 | 0.73 | SPHK2 (0.59) | ADAM17 | |
| SCHEMBL6595241 | 0.73 | ADAM17 (0.85) | ADAM17MMP13ADAMTS4MMP3MMP7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1263756-B1 | BETA-AMINO ACID DERIVATIVES AS INHIBITORS OF MATRIX METALLOPROTEASES AND TNF-ALPHA | BRISTOL MYERS SQUIBB PHARMA CO (US) | 2004-02-25 | — | — | EP | claimed |