SCHEMBL6607004

SCHEMBL6607004

Cc1nnsc1-c1nc(C(=O)Nc2cccc(OCCN(C(C)C)C(C)C)c2)cs1

nearest known ligand 0.45

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
IRAK4 Q9NWZ3 2/20 0.45
ALDH1A1 P00352 2/20 0.44
MAPT P10636 2/20 0.44
THRB P10828 2/20 0.41
MAP3K5 Q99683 1/20 0.41
MCHR1 Q99705 6/20 0.40
LMNA P02545 2/20 0.40
KDM4E B2RXH2 1/20 0.40
MEN1 O00255 1/20 0.40
GAA P10253 1/20 0.40
HPGD P15428 1/20 0.40
KMT2A Q03164 1/20 0.40
ATM Q13315 1/20 0.40
SMN1; SMN2 Q16637 1/20 0.40
NPSR1 Q6W5P4 1/20 0.40
L3MBTL1 Q9Y468 1/20 0.40
USP36 Q9P275 1/20 0.39
GRM4 Q14833 2/20 0.38
TDP1 Q9NUW8 1/20 0.38
NR3C1 P04150 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6607011 0.88 ALDH1A1 (0.46) IRAK4ALDH1A1MAPTTHRBMAP3K5
SCHEMBL6604027 0.85 MAPT (0.58) IRAK4ALDH1A1MAPTMCHR1LMNA
SCHEMBL6615547 0.85 MCHR1 (0.49) ALDH1A1MAPTMCHR1KDM4ESMN1; SMN2
SCHEMBL6604067 0.84 IRAK4 (0.56) IRAK4ALDH1A1MAPTMCHR1LMNA
SCHEMBL6603701 0.84 IRAK4 (0.45) IRAK4ALDH1A1MAPTTHRBMAP3K5
SCHEMBL6603342 0.83 PANK3 (0.53) IRAK4ALDH1A1MAPTTHRBMCHR1
SCHEMBL6604053 0.80 MAPK1 (0.57) IRAK4ALDH1A1MAPTMCHR1LMNA
SCHEMBL6604994 0.79 NPSR1 (0.55) IRAK4ALDH1A1MAPTMCHR1LMNA
SCHEMBL6604450 0.74 ROCK1 (0.54) MAPTMCHR1MEN1KMT2A
SCHEMBL6603115 0.74 MCHR1 (0.48) ALDH1A1MAPTMCHR1LMNAKDM4E

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1102535-A4 COMPOUNDS AND METHODS SMITHKLINE BEECHAM CORP (US) 2004-09-29 EP disclosed
US-6399656-B1 USING A BENZOPYRAN-3-CARBOXAMIDE COMPOUND SMITHKLINE BEECHAM CORPORATION 2002-06-04 US disclosed
EP-1102535-A2 COMPOUNDS AND METHODS SmithKline Beecham Corporation (US) 2001-05-30 EP disclosed
WO-2000006085-A2 COMPOUNDS AND METHODS SMITHKLINE BEECHAM CORPORATION (US) 2000-02-10 WO disclosed