Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDGFRB | P09619 | 5/20 | 0.43 |
| ▸ | PDGFRA | P16234 | 5/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | AR | P10275 | 1/20 | 0.32 |
| ▸ | MAOA | P21397 | 2/20 | 0.31 |
| ▸ | MAOB | P27338 | 2/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | BCL2 | P10415 | 2/20 | 0.31 |
| ▸ | HPGD | P15428 | 1/20 | 0.31 |
| ▸ | ATM | Q13315 | 2/20 | 0.31 |
| ▸ | PDE4A | P27815 | 2/20 | 0.31 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.31 |
| ▸ | PDE4C | Q08493 | 2/20 | 0.31 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.31 |
| ▸ | QRFPR | Q96P65 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6605575 | 0.76 | PDE4B (0.44) | PDGFRBPDGFRALMNAPDE4APDE4B | |
| SCHEMBL15142441 | 0.70 | AXL (0.35) | ALDH1A1KDM4EHTTHPGD | |
| SCHEMBL6606419 | 0.70 | MDM2 (0.36) | ALDH1A1KDM4EHTTHPGD | |
| SCHEMBL6606117 | 0.68 | PDGFRB (0.35) | PDGFRBPDGFRAALDH1A1KDM4EHTT | |
| SCHEMBL6608302 | 0.68 | KDM4E (0.36) | ALDH1A1KDM4EHTTLMNA | |
| SCHEMBL6605813 | 0.68 | POLB (0.44) | PDGFRBPDGFRAALDH1A1KDM4EPDE4A | |
| SCHEMBL6609750 | 0.67 | PDE4B (0.44) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL6607129 | 0.66 | PDE4B (0.50) | PDGFRBPDGFRAPDE4APDE4BPDE4C | |
| SCHEMBL6606573 | 0.66 | PDE3B (0.36) | ARPDE4APDE4BPDE4CPDE4D | |
| SCHEMBL6606602 | 0.65 | PDE4B (0.44) | PDE4APDE4BPDE4CPDE4D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0882714-B1 | SUBSTITUTED VINYLPYRIDINE DERIVATIVES AND DRUGS CONTAINING THE SAME | SS PHARMACEUTICAL CO (JP) | 2004-03-03 | — | — | EP | disclosed |
| US-5935977-A | PHOSPHODIESTERASE IV INHIBITORS, TUMOR NECROSIS FACTOR-ALPHA PRODUCTION INHIBITORS; TREATING INFLAMMATORY AND AUTOIMMUNE DISEASES | SS PHARMACEUTICAL CO., LTD. (JP) | 1999-08-10 | — | — | US | disclosed |
| EP-0882714-A1 | SUBSTITUTED VINYLPYRIDINE DERIVATIVES AND DRUGS CONTAINING THE SAME | SS Pharmaceutical Co., Ltd. (JP) | 1998-12-09 | — | — | EP | disclosed |