Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | VKORC1 | Q9BQB6 | 1/20 | 0.55 |
| ▸ | TYMP | P19971 | 1/20 | 0.54 |
| ▸ | GPR55 | Q9Y2T6 | 5/20 | 0.54 |
| ▸ | CNR1 | P21554 | 3/20 | 0.54 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.52 |
| ▸ | MAPT | P10636 | 2/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.51 |
| ▸ | HPGD | P15428 | 2/20 | 0.51 |
| ▸ | CASP3 | P42574 | 1/20 | 0.51 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.51 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.51 |
| ▸ | CNR2 | P34972 | 4/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | F2 | P00734 | 1/20 | 0.47 |
| ▸ | HTR1A | P08908 | 1/20 | 0.46 |
| ▸ | DRD2 | P14416 | 1/20 | 0.46 |
| ▸ | HTR2B | P41595 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5215534 | 0.86 | MAPT (0.60) | VKORC1TYMPGPR55L3MBTL1MAPT | |
| SCHEMBL6605495 | 0.81 | TYMP (0.63) | TYMPGPR55L3MBTL1MAPTALDH1A1 | |
| SCHEMBL1856108 | 0.75 | CNR2 (0.46) | GPR55CNR1CNR2KMT2AHTR1A | |
| SCHEMBL6600286 | 0.75 | LOXL2 (0.50) | VKORC1MAPTCASP3SENP7KMT2A | |
| SCHEMBL5218977 | 0.73 | TYMP (0.57) | TYMPGPR55L3MBTL1MAPTALDH1A1 | |
| SCHEMBL31716273 | 0.73 | TYMP (0.57) | VKORC1TYMPGPR55L3MBTL1MAPT | |
| SCHEMBL8116697 | 0.73 | VKORC1 (0.51) | VKORC1GPR55CNR1CNR2KMT2A | |
| SCHEMBL10725654 | 0.72 | MAPT (0.67) | TYMPL3MBTL1MAPTALDH1A1HPGD | |
| SCHEMBL6605667 | 0.71 | MAPT (0.61) | TYMPL3MBTL1MAPTTDP1HTR2B | |
| SCHEMBL2099512 | 0.71 | CHRM2 (0.66) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1397350-A1 | ISOQUINOLINONE DERIVATIVES AS PARP INHIBITORS | Kudos Pharmaceuticals Limited (GB) | 2004-03-17 | — | — | EP | disclosed |
| US-6664269-B2 | Adminisetring isoquinolinone compounds for therapy of disease mediated by the enzyme poly(ADP- ribose)polymerase (\"PARP\") | MAYBRIDGE PLC (GB) | 2003-12-16 | — | — | US | disclosed |
| US-20030008896-A1 | Isoquinolinone derivatives | KUDOS PHARMACEUTICALS LIMITED (GB) | 2003-01-09 | — | — | US | disclosed |
| WO-2002090334-A1 | ISOQUINOLINONE DERIVATIVES AS PARP INHIBITORS | KUDOS PHARMACEUTICALS LIMITED (GB) | 2002-11-14 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030008896-A1 | Isoquinolinone derivatives | PARP1, PARP2, PARP3 | VKORC1 2882/4885TYMP 65/4885GPR55 3453/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.