Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSK | P43235 | 12/20 | 0.71 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.51 |
| ▸ | HTT | P42858 | 2/20 | 0.51 |
| ▸ | NPC1 | O15118 | 3/20 | 0.50 |
| ▸ | RAB9A | P51151 | 3/20 | 0.50 |
| ▸ | PKM | P14618 | 2/20 | 0.50 |
| ▸ | CTSV | O60911 | 1/20 | 0.49 |
| ▸ | CTSS | P25774 | 1/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | EHMT2 | Q96KQ7 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6604125 | 1.00 | CTSK (0.71) | CTSKALOX12SMN1; SMN2HTTNPC1 | |
| SCHEMBL5637491 | 0.78 | CTSK (0.53) | CTSK | |
| SCHEMBL5637506 | 0.78 | CTSK (0.53) | CTSK | |
| SCHEMBL6616469 | 0.77 | HTT (0.50) | CTSKALOX12SMN1; SMN2HTTNPC1 | |
| SCHEMBL6406963 | 0.77 | HTT (0.50) | CTSKALOX12SMN1; SMN2HTTNPC1 | |
| SCHEMBL6402731 | 0.77 | HTT (0.50) | CTSKALOX12SMN1; SMN2HTTNPC1 | |
| SCHEMBL6402737 | 0.77 | HTT (0.50) | CTSKALOX12SMN1; SMN2HTTNPC1 | |
| SCHEMBL6406973 | 0.77 | HTT (0.50) | CTSKALOX12SMN1; SMN2HTTNPC1 | |
| SCHEMBL6606767 | 0.77 | CTSK (0.71) | CTSKSMN1; SMN2HTTPKMCTSV | |
| SCHEMBL6606757 | 0.77 | CTSK (0.71) | CTSKSMN1; SMN2HTTPKMCTSV |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1411933-A1 | ALPHA-KETOAMIDE DERIVATIVES AS CATHEPSIN K INHIBITORS | SmithKline Beecham Corporation (US) | 2004-04-28 | — | — | EP | claimed |
| WO-2003013518-A1 | ALPHA-KETOAMIDE DERIVATIVES AS CATHEPSIN K INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 2003-02-20 | — | — | WO | claimed |