Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 1/20 | 0.43 |
| ▸ | KDR | P35968 | 4/20 | 0.41 |
| ▸ | LCK | P06239 | 2/20 | 0.41 |
| ▸ | SRC | P12931 | 1/20 | 0.41 |
| ▸ | PDE2A | O00408 | 1/20 | 0.40 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.39 |
| ▸ | EGFR | P00533 | 4/20 | 0.39 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.39 |
| ▸ | FLT1 | P17948 | 1/20 | 0.39 |
| ▸ | FLT4 | P35916 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | EPHA2 | P29317 | 1/20 | 0.38 |
| ▸ | EPHB4 | P54760 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | ATM | Q13315 | 1/20 | 0.38 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.37 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.37 |
| ▸ | ADCY10 | Q96PN6 | 1/20 | 0.37 |
| ▸ | HTR2C | P28335 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6600560 | 0.94 | PDE2A (0.40) | SYKKDRSRCPDE2AMKNK1 | |
| SCHEMBL6493240 | 0.82 | KDR (0.56) | SYKKDRLCKSRCEGFR | |
| SCHEMBL6479597 | 0.80 | KDR (0.57) | KDRLCKSRCEGFRFGFR1 | |
| SCHEMBL14380859 | 0.67 | KDR (0.51) | KDRLCKSRCMKNK1EGFR | |
| SCHEMBL6478952 | 0.66 | KDR (0.74) | KDRLCKSRCEGFRFGFR1 | |
| SCHEMBL12435658 | 0.66 | SYK (0.77) | SYKCYP2D6TSHRHTR2CHTR2B | |
| SCHEMBL4088385 | 0.65 | SYK (0.59) | SYKKDRCYP2D6TSHREPHA2 | |
| SCHEMBL2088116 | 0.64 | SYK (0.65) | SYKSRCCYP2D6TSHRHTR2C | |
| SCHEMBL6479352 | 0.64 | KDR (0.54) | KDRLCKSRCEGFRFGFR1 | |
| SCHEMBL18167155 | 0.64 | SYK (0.47) | SYKKDRLCKSRCEGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1385833-A1 | TRIAZINYL AMIDE DERIVATIVES AS ANGIOGENESIS INHIBITORS | Amgen Inc. (US) | 2004-02-04 | — | — | EP | disclosed |
| WO-2002083654-A1 | TRIAZINYL AMIDE DERIVATIVES AS ANGIOGENESIS INHIBITORS | AMGEN INC. (US) | 2002-10-24 | — | — | WO | disclosed |