Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HIF1A | Q16665 | 1/20 | 0.36 |
| ▸ | EPAS1 | Q99814 | 1/20 | 0.36 |
| ▸ | PDE10A | Q9Y233 | 6/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | PTGES | O14684 | 1/20 | 0.34 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.33 |
| ▸ | RAB9A | P51151 | 2/20 | 0.33 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | MMP1 | P03956 | 1/20 | 0.32 |
| ▸ | FCER2 | P06734 | 1/20 | 0.32 |
| ▸ | MMP3 | P08254 | 1/20 | 0.32 |
| ▸ | MMP9 | P14780 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6399028 | 0.92 | HIF1A (0.35) | HIF1AEPAS1PDE10ACYP1A2PTGES | |
| SCHEMBL6606815 | 0.90 | PDE10A (0.36) | HIF1AEPAS1PDE10ACYP1A2PTGES | |
| SCHEMBL6399798 | 0.90 | HIF1A (0.37) | HIF1AEPAS1PDE10ACYP1A2KMT2A | |
| SCHEMBL6606605 | 0.89 | HPGD (0.38) | HIF1AEPAS1PDE10ACYP1A2PTGES | |
| Hydrochloric Acid SCHEMBL6404910 | 0.86 | HIF1A (0.31) | HIF1AEPAS1CYP1A2MMP1FCER2 | |
| SCHEMBL6662759 | 0.84 | HIF1A (0.36) | HIF1AEPAS1PDE10ACYP1A2KMT2A | |
| SCHEMBL6400329 | 0.84 | CYP1A2 (0.35) | HIF1AEPAS1PDE10ACYP1A2PTGES | |
| SCHEMBL6077244 | 0.84 | HIF1A (0.36) | HIF1AEPAS1PDE10ACYP1A2KMT2A | |
| SCHEMBL6401582 | 0.83 | CYP1A2 (0.38) | HIF1AEPAS1PDE10ACYP1A2PTGES | |
| SCHEMBL6400533 | 0.83 | CYP1A2 (0.38) | HIF1AEPAS1PDE10ACYP1A2PTGES |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1289980-B1 | BICYCLYL OR HETEROBICYCLYLMETHANESULFONYLAMINO-SUBSTITUTED N-HYDROXYFORMAMIDES | SMITHKLINE BEECHAM PLC (GB) | 2004-11-17 | — | — | EP | disclosed |