Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HIF1A | Q16665 | 1/20 | 0.36 |
| ▸ | EPAS1 | Q99814 | 1/20 | 0.36 |
| ▸ | PDE10A | Q9Y233 | 9/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | TRPM5 | Q9NZQ8 | 1/20 | 0.33 |
| ▸ | ALPL | P05186 | 1/20 | 0.32 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.32 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.32 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.32 |
| ▸ | CNR2 | P34972 | 1/20 | 0.32 |
| ▸ | MMP2 | P08253 | 1/20 | 0.32 |
| ▸ | MMP13 | P45452 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6077244 | 0.87 | HIF1A (0.36) | HIF1AEPAS1PDE10ACYP1A2KDM4E | |
| SCHEMBL6990550 | 0.85 | HIF1A (0.38) | HIF1AEPAS1PDE10ACYP1A2KDM4E | |
| SCHEMBL6399798 | 0.84 | HIF1A (0.37) | HIF1AEPAS1PDE10ACYP1A2KDM4E | |
| SCHEMBL6606815 | 0.84 | PDE10A (0.36) | HIF1AEPAS1PDE10ACYP1A2KDM4E | |
| SCHEMBL6607311 | 0.84 | HIF1A (0.36) | HIF1AEPAS1PDE10ACYP1A2KDM4E | |
| SCHEMBL6661883 | 0.83 | PDE10A (0.35) | HIF1AEPAS1PDE10AKDM4EKMT2A | |
| SCHEMBL6606605 | 0.83 | HPGD (0.38) | HIF1AEPAS1PDE10ACYP1A2KDM4E | |
| SCHEMBL6399028 | 0.82 | HIF1A (0.35) | HIF1AEPAS1PDE10ACYP1A2KDM4E | |
| SCHEMBL6985491 | 0.82 | HIF1A (0.36) | HIF1AEPAS1PDE10ACYP1A2KDM4E | |
| SCHEMBL6982449 | 0.80 | HIF1A (0.35) | HIF1AEPAS1PDE10ACYP1A2KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1448529-A1 | SULFONE DERIVATIVES AND THEIR USE IN THE TREATMENT OF AUTOIMMUNE DISEASES AND ALLERGIES | SMITHKLINE BEECHAM PLC (GB) | 2004-08-25 | — | — | EP | disclosed |
| WO-2003045922-A1 | SULFONE DERIVATIVES AND THEIR USE IN THE TREATMENT OF AUTOIMMUNE DISEASES AND ALLERGIES | SMITHKLINE BEECHAM P.L.C. (GB) | 2003-06-05 | — | — | WO | disclosed |