Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IDH1 | O75874 | 8/20 | 0.37 |
| ▸ | QPCT | Q16769 | 6/20 | 0.34 |
| ▸ | STING1 | Q86WV6 | 2/20 | 0.34 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.33 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.33 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.33 |
| ▸ | BPTF | Q12830 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6625580 | 1.00 | IDH1 (0.37) | IDH1QPCTSTING1HDAC1HDAC8 | |
| SCHEMBL6625404 | 0.88 | STING1 (0.33) | IDH1QPCTSTING1 | |
| SCHEMBL6607697 | 0.88 | STING1 (0.33) | IDH1QPCTSTING1 | |
| SCHEMBL6622011 | 0.82 | IDH1 (0.37) | IDH1STING1 | |
| SCHEMBL2107339 | 0.77 | IDH1 (0.38) | IDH1QPCTHDAC1HDAC8HDAC6 | |
| SCHEMBL6608322 | 0.76 | F10 (0.46) | — | |
| SCHEMBL6607578 | 0.76 | F10 (0.46) | — | |
| SCHEMBL8125549 | 0.75 | HDAC1 (0.35) | IDH1QPCTHDAC1HDAC8HDAC6 | |
| SCHEMBL6675442 | 0.72 | MAOB (0.47) | QPCT | |
| SCHEMBL6098143 | 0.72 | CMA1 (0.36) | IDH1QPCTBPTF |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1448536-A1 | CYCLOPROPYL-CONTAINING OXAZOLIDINONE ANTIBIOTICS AND DERIVATIVES THEREOF | Merck & Co., Inc. (US) | 2004-08-25 | — | — | EP | disclosed |
| WO-2003048136-A1 | CYCLOPROPYL HEXANE CONTAINING OXAZOLIDINONE ANTIBIOTICS AND DERIVATIVES THEREOF | MERCK & CO., INC. (US) | 2003-06-12 | — | — | WO | disclosed |