Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.45 |
| ▸ | HCAR3 | P49019 | 3/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.39 |
| ▸ | NPC1 | O15118 | 5/20 | 0.39 |
| ▸ | RAB9A | P51151 | 5/20 | 0.39 |
| ▸ | GLA | P06280 | 2/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.39 |
| ▸ | HTT | P42858 | 2/20 | 0.39 |
| ▸ | CASP3 | P42574 | 1/20 | 0.39 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.39 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.39 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.38 |
| ▸ | RECQL | P46063 | 1/20 | 0.38 |
| ▸ | KCNMA1 | Q12791 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6607273 | 0.83 | MAPT (0.45) | MAPTNPSR1HCAR3ALDH1A1NPC1 | |
| SCHEMBL7698657 | 0.82 | MAPT (0.49) | MAPTHCAR3ALDH1A1NPC1RAB9A | |
| SCHEMBL6165036 | 0.82 | MAPT (0.40) | MAPTNPSR1HCAR3ALDH1A1NPC1 | |
| SCHEMBL6608184 | 0.80 | MAPT (0.42) | MAPTNPSR1HCAR3ALDH1A1NPC1 | |
| SCHEMBL6608481 | 0.78 | CXCR2 (0.43) | MAPTHCAR3ALDH1A1NPC1RAB9A | |
| SCHEMBL7700537 | 0.77 | MAPT (0.46) | MAPTALDH1A1NPC1RAB9AMAPK1 | |
| SCHEMBL6881721 | 0.75 | KMT2A (0.42) | MAPTNPSR1HCAR3ALDH1A1NPC1 | |
| SCHEMBL7704022 | 0.74 | NPC1 (0.41) | MAPTNPSR1ALDH1A1NPC1RAB9A | |
| SCHEMBL980547 | 0.74 | MAPT (0.78) | MAPTNPSR1HCAR3ALDH1A1NPC1 | |
| SCHEMBL980549 | 0.74 | MAPT (0.78) | MAPTNPSR1HCAR3ALDH1A1NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1379511-A1 | DIHYDRO-BENZO (b) (1, 4) DIAZEPIN-2-ONE DERIVATIVES AS MGLUR2 ANTAGONISTS II | F. HOFFMANN-LA ROCHE AG (CH) | 2004-01-14 | — | — | EP | disclosed |
| WO-2002083652-A1 | DIHYDRO-BENZO [b] [1, 4] DIAZEPIN-2-ONE DERIVATIVES AS MGLUR2 ANTAGONISTS II | F. HOFFMANN-LA ROCHE AG (CH) | 2002-10-24 | — | — | WO | disclosed |