Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.46 |
| ▸ | NPC1 | O15118 | 2/20 | 0.46 |
| ▸ | RAB9A | P51151 | 2/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | ABCB1 | P08183 | 8/20 | 0.46 |
| ▸ | ABCC1 | P33527 | 6/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1694595 | 0.88 | MAPT (0.49) | MAPTSMN1; SMN2NPC1RAB9AMAPK1 | |
| SCHEMBL7704022 | 0.85 | NPC1 (0.41) | MAPTSMN1; SMN2NPC1RAB9AMAPK1 | |
| SCHEMBL18306153 | 0.83 | MAPT (0.48) | MAPTSMN1; SMN2NPC1RAB9AMAPK1 | |
| SCHEMBL7141612 | 0.83 | PKM (0.43) | MAPTSMN1; SMN2ABCB1ABCC1ALDH1A1 | |
| SCHEMBL7698574 | 0.82 | NPC1 (0.49) | MAPTSMN1; SMN2NPC1RAB9AMAPK1 | |
| SCHEMBL7698657 | 0.82 | MAPT (0.49) | MAPTSMN1; SMN2NPC1RAB9AMAPK1 | |
| SCHEMBL21816628 | 0.80 | HCAR3 (0.48) | MAPTSMN1; SMN2NPC1RAB9AMAPK1 | |
| SCHEMBL7704609 | 0.79 | KDM4E (0.43) | MAPTSMN1; SMN2NPC1RAB9AMAPK1 | |
| SCHEMBL18306145 | 0.78 | ALDH1A1 (0.52) | MAPTSMN1; SMN2ALDH1A1CYP3A4TDP1 | |
| SCHEMBL6608481 | 0.78 | CXCR2 (0.43) | MAPTNPC1RAB9AALDH1A1CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1224174-A2 | BENZODIAZEPINE DERIVATIVES AS METABOTROPIC GLUTAMATE RECEPTOR ANTAGONISTS | F. HOFFMANN-LA ROCHE AG (CH) | 2002-07-24 | — | — | EP | disclosed |
| WO-2001029011-A2 | BENZODIAZEPINE DERIVATIVES AS METABOTROPIC GLUTAMATE RECEPTOR ANTAGONISTS | F. HOFFMANN-LA ROCHE AG (CH) | 2001-04-26 | — | — | WO | disclosed |