Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE | P22303 | 17/20 | 0.52 |
| ▸ | BCHE | P06276 | 14/20 | 0.52 |
| ▸ | PDE5A | O76074 | 2/20 | 0.49 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.49 |
| ▸ | GRIN1 | Q05586 | 3/20 | 0.48 |
| ▸ | GRIN2A | Q12879 | 3/20 | 0.48 |
| ▸ | APP | P05067 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6609348 | 0.82 | MAPT (0.61) | ACHEBCHEPDE5AGRIN1GRIN2A | |
| SCHEMBL6608783 | 0.82 | ACHE (0.68) | ACHEBCHECHRM1GRIN1GRIN2A | |
| SCHEMBL16401333 | 0.82 | ACHE (0.54) | ACHEBCHEPDE5ACHRM1GRIN1 | |
| SCHEMBL6605996 | 0.82 | BCHE (0.45) | ACHEBCHEPDE5AGRIN1GRIN2A | |
| SCHEMBL6609155 | 0.79 | MAPT (0.47) | ACHEBCHEAPP | |
| SCHEMBL11828040 | 0.77 | ACHE (0.53) | ACHEBCHECHRM1GRIN1GRIN2A | |
| SCHEMBL11848739 | 0.77 | ACHE (0.56) | ACHEBCHECHRM1GRIN1GRIN2A | |
| SCHEMBL24844122 | 0.71 | EHMT2 (0.73) | ACHEBCHEGRIN1GRIN2A | |
| SCHEMBL30064006 | 0.71 | EHMT2 (0.70) | ACHEBCHECHRM1 | |
| SCHEMBL24843945 | 0.71 | EHMT2 (0.70) | ACHEBCHECHRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0997462-A1 | NOVEL NAPHTHYRIDINE DERIVATIVES OR SALTS THEREOF | Nippon Kayaku Kabushiki Kaisha (JP) | 2000-05-03 | — | — | EP | claimed |
| EP-0997462-B1 | NOVEL NAPHTHYRIDINE DERIVATIVES OR SALTS THEREOF | NIPPON KAYAKU KK (JP) | 2004-12-22 | — | — | EP | disclosed |
| US-6294547-B1 | Naphthyridine deratives or salts thereof | NIPPON KAYAKU KABUSHIKI KAISHA (JP) | 2001-09-25 | — | — | US | disclosed |
| EP-0997462-A1 | NOVEL NAPHTHYRIDINE DERIVATIVES OR SALTS THEREOF | Nippon Kayaku Kabushiki Kaisha (JP) | 2000-05-03 | — | — | EP | disclosed |