Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.31 |
| ▸ | GRM5 | P41594 | 1/20 | 0.31 |
| ▸ | NPC1 | O15118 | 1/20 | 0.31 |
| ▸ | RAB9A | P51151 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6534796 | 0.82 | GRM5 (0.32) | KDM4CGRM5NPC1RAB9A | |
| SCHEMBL1004656 | 0.82 | KDM4C (0.36) | MEN1KMT2AKDM4CGRM5NPC1 | |
| SCHEMBL7881560 | 0.78 | MEN1 (0.33) | MEN1KMT2AKDM4CGRM5ALDH1A1 | |
| SCHEMBL6535768 | 0.78 | KDM4C (0.31) | KDM4CGRM5NPC1RAB9A | |
| SCHEMBL23014903 | 0.77 | MEN1 (0.35) | MEN1KMT2AALDH1A1TDP1 | |
| SCHEMBL23014928 | 0.77 | MEN1 (0.35) | MEN1KMT2AALDH1A1TDP1 | |
| SCHEMBL23014986 | 0.77 | MEN1 (0.35) | MEN1KMT2AALDH1A1TDP1 | |
| SCHEMBL10814170 | 0.77 | MEN1 (0.35) | MEN1KMT2AALDH1A1TDP1 | |
| SCHEMBL2478287 | 0.77 | MEN1 (0.35) | MEN1KMT2AALDH1A1TDP1 | |
| SCHEMBL23015059 | 0.77 | MEN1 (0.35) | MEN1KMT2AALDH1A1TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1379522-A1 | DIHYDRO-BENZO(b)(1,4)DIAZEPIN-2-ONE DERIVATIVES AS MGLUR2 ANTAGONISTS I | F. HOFFMANN-LA ROCHE AG (CH) | 2004-01-14 | — | — | EP | disclosed |
| EP-1379511-A1 | DIHYDRO-BENZO (b) (1, 4) DIAZEPIN-2-ONE DERIVATIVES AS MGLUR2 ANTAGONISTS II | F. HOFFMANN-LA ROCHE AG (CH) | 2004-01-14 | — | — | EP | disclosed |
| WO-2002083652-A1 | DIHYDRO-BENZO [b] [1, 4] DIAZEPIN-2-ONE DERIVATIVES AS MGLUR2 ANTAGONISTS II | F. HOFFMANN-LA ROCHE AG (CH) | 2002-10-24 | — | — | WO | disclosed |
| WO-2002083665-A1 | DIHYDRO-BENZO[b][1,4]DIAZEPIN-2-ONE DERIVATIVES AS MGLUR2 ANTAGONISTS I | F. HOFFMANN-LA ROCHE AG (CH) | 2002-10-24 | — | — | WO | disclosed |