Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAF1 | P04049 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | CCNC | P24863 | 1/20 | 0.39 |
| ▸ | CDK8 | P49336 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.39 |
| ▸ | MEN1 | O00255 | 4/20 | 0.39 |
| ▸ | POLB | P06746 | 2/20 | 0.39 |
| ▸ | ALOX5 | P09917 | 2/20 | 0.38 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.38 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.38 |
| ▸ | GCGR | P47871 | 1/20 | 0.38 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.38 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.38 |
| ▸ | IDO1 | P14902 | 2/20 | 0.38 |
| ▸ | GLA | P06280 | 2/20 | 0.38 |
| ▸ | GAA | P10253 | 2/20 | 0.38 |
| ▸ | HPGD | P15428 | 2/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3829650 | 0.82 | RAF1 (0.39) | RAF1KDM4ECCNCCDK8KMT2A | |
| SCHEMBL3826599 | 0.82 | MEN1 (0.37) | RAF1KDM4EALDH1A1CCNCCDK8 | |
| SCHEMBL3824756 | 0.82 | SELP (0.40) | RAF1KDM4EALDH1A1CCNCCDK8 | |
| SCHEMBL3824090 | 0.81 | SELP (0.41) | RAF1KDM4EALDH1A1CCNCCDK8 | |
| SCHEMBL3824754 | 0.71 | ALOX5 (0.41) | KDM4EKMT2AMEN1POLBALOX5 | |
| SCHEMBL13679655 | 0.70 | PTPN1 (0.46) | RAF1KDM4EALDH1A1KMT2AMEN1 | |
| SCHEMBL13780575 | 0.68 | MAPT (0.47) | KDM4EALDH1A1KMT2AMEN1MAPT | |
| SCHEMBL8541449 | 0.68 | CCNC (0.48) | KDM4EALDH1A1CCNCCDK8KMT2A | |
| SCHEMBL13679673 | 0.67 | PTPN1 (0.43) | RAF1KDM4EALDH1A1KMT2AMEN1 | |
| SCHEMBL13803933 | 0.67 | NISCH (0.63) | KDM4EALDH1A1KMT2AMEN1CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0999835-A4 | IMIDAZOLE DERIVATIVES AS MDR MODULATORS | ONTOGEN CORP (US) | 2004-08-25 | — | — | EP | disclosed |
| EP-0999835-A1 | IMIDAZOLE DERIVATIVES AS MDR MODULATORS | Ontogen Corporation (US) | 2000-05-17 | — | — | EP | disclosed |
| WO-1999002155-A1 | IMIDAZOLE DERIVATIVES AS MDR MODULATORS | ONTOGEN CORPORATION (US) | 1999-01-21 | — | — | WO | disclosed |