Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4B | Q07343 | 4/20 | 0.41 |
| ▸ | PDE4A | P27815 | 2/20 | 0.41 |
| ▸ | PDE4C | Q08493 | 2/20 | 0.41 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.41 |
| ▸ | SMPD1 | P17405 | 4/20 | 0.40 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.40 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.40 |
| ▸ | ENPP1 | P22413 | 1/20 | 0.36 |
| ▸ | PRKCE | Q02156 | 1/20 | 0.36 |
| ▸ | PRKCQ | Q04759 | 1/20 | 0.36 |
| ▸ | PRKCD | Q05655 | 1/20 | 0.36 |
| ▸ | FAAH | O00519 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9915311 | 0.93 | CYP1A2 (0.37) | PDE4BPDE4APDE4CPDE4D | |
| SCHEMBL6609628 | 0.85 | PDE4B (0.41) | PDE4BPDE4APDE4CPDE4DSMPD1 | |
| SCHEMBL21749946 | 0.84 | S1PR1 (0.44) | PDE4BPDE4APDE4CPDE4DENPP1 | |
| SCHEMBL30918494 | 0.84 | PDE4A (0.47) | PDE4BPDE4APDE4CPDE4D | |
| SCHEMBL3930071 | 0.84 | PDE4A (0.47) | PDE4BPDE4APDE4CPDE4D | |
| SCHEMBL6606573 | 0.81 | PDE3B (0.36) | PDE4BPDE4APDE4CPDE4DSMPD1 | |
| SCHEMBL11850880 | 0.81 | ALOX5 (0.42) | PDE4BPDE4APDE4CPDE4D | |
| Hydrochloric Acid SCHEMBL11843645 | 0.80 | DPP4 (0.43) | PDE4BPDE4APDE4CPDE4D | |
| SCHEMBL6608408 | 0.79 | PDE4A (0.36) | PDE4BPDE4APDE4CPDE4D | |
| SCHEMBL6610798 | 0.79 | PDE4A (0.48) | PDE4BPDE4APDE4CPDE4D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0882714-B1 | SUBSTITUTED VINYLPYRIDINE DERIVATIVES AND DRUGS CONTAINING THE SAME | SS PHARMACEUTICAL CO (JP) | 2004-03-03 | — | — | EP | disclosed |
| US-5935977-A | PHOSPHODIESTERASE IV INHIBITORS, TUMOR NECROSIS FACTOR-ALPHA PRODUCTION INHIBITORS; TREATING INFLAMMATORY AND AUTOIMMUNE DISEASES | SS PHARMACEUTICAL CO., LTD. (JP) | 1999-08-10 | — | — | US | disclosed |
| EP-0882714-A1 | SUBSTITUTED VINYLPYRIDINE DERIVATIVES AND DRUGS CONTAINING THE SAME | SS Pharmaceutical Co., Ltd. (JP) | 1998-12-09 | — | — | EP | disclosed |