Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.55 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.54 |
| ▸ | PPARG | P37231 | 4/20 | 0.50 |
| ▸ | PPARA | Q07869 | 4/20 | 0.50 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.48 |
| ▸ | SRC | P12931 | 1/20 | 0.48 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 2/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13324879 | 1.00 | KDM4E (0.55) | KDM4EALDH1A1CHRM1PPARGPPARA | |
| SCHEMBL21881586 | 1.00 | KDM4E (0.55) | KDM4EALDH1A1CHRM1PPARGPPARA | |
| Hydrogen Sulfide SCHEMBL28780976 | 0.98 | KDM4E (0.54) | KDM4EALDH1A1CHRM1PPARGPPARA | |
| SCHEMBL11568688 | 0.88 | PPARG (0.54) | KDM4EALDH1A1CHRM1PPARGPPARA | |
| SCHEMBL14889080 | 0.87 | PPARG (0.67) | PPARGPPARAMEN1KMT2A | |
| SCHEMBL21881560 | 0.87 | MEN1 (0.58) | KDM4EALDH1A1CHRM1PPARGPPARA | |
| SCHEMBL7411362 | 0.87 | KDM4E (0.52) | KDM4EALDH1A1CHRM1PPARGPPARA | |
| SCHEMBL21881525 | 0.87 | PPARG (0.59) | KDM4EALDH1A1PPARGPPARAMEN1 | |
| SCHEMBL5944601 | 0.87 | MEN1 (0.58) | KDM4EALDH1A1CHRM1PPARGPPARA | |
| SCHEMBL8935861 | 0.87 | KDM4E (0.52) | KDM4EALDH1A1CHRM1PPARGPPARA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 311 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-103539760-B | (phenoxy) phenylacetic acid class endothelin antagonist and preparation method thereof and application | SOUTHEAST UNIVERSITY (CN) | 2016-04-13 | — | — | CN | claimed |
| CN-103539760-A | Phenoxy phenylacetic acid endothelin antagonist, and preparation method and application thereof | UNIV SOUTHEAST | 2014-01-29 | — | — | CN | claimed |
| CN-101180379-B | Dihydroxy enol compounds used in chemical mechanical polishing compositions having metal ion oxidizers | AIR PROD & CHEM | 2013-07-24 | — | — | CN | claimed |
| CN-102731466-A | Diarylo[d,f]oxa-cycloheptane-3-ketone compound and synthesis method thereof | UNIV HEILONGJIANG | 2012-10-17 | — | — | CN | claimed |
| US-20120046308-A1 | NOVEL ALPHA-PHENOXYBENZENEACETIC ACID DERIVATIVE AND PHARMACEUTICAL PREPARATION COMPRISING SAME | KOWA COMPANY, LTD. (JP) | 2012-02-23 | — | — | US | claimed |
| WO-2009080835-A1 | THYROMIMETRIC COMPOUNDS IN TREATMENT OF DISEASE RELATED TO SONIC HEDGEHOG SIGNALLING | KARO BIO AB (SE) | 2009-07-02 | — | — | WO | claimed |
| CN-101180379-A | Dihydroxy enol compounds used in chemical mechanical polishing compositions having metal ion oxidizers | DUPONT AIR PROD NANOMATERIALS (US) | 2008-05-14 | — | — | CN | claimed |
| US-20070203243-A1 | RESOLUTION OF ALPHA-(PHENOXY) PHENYLACETIC ACID DERIVATIVES | METABOLEX, INC. (US) | 2007-08-30 | — | — | US | claimed |
| US-7199259-B2 | Resolution of α-(phenoxy)phenylacetic acid derivatives | METABOLEX, INC. (US) | 2007-04-03 | — | — | US | claimed |
| EP-1635809-A4 | RESOLUTION OF ALPHA-(PHENOXY)PHENYLACETIC ACID DERIVATIVES | METABOLEX INC (US) | 2006-09-27 | — | — | EP | claimed |
| JP-2001501449-A | — | — | 2001-02-06 | — | — | JP | claimed |
| EP-0873334-A1 | PROCESS FOR THE PREPARATION OF AN ENDOTHELIN ANTAGONIST | Merck & Co., Inc. (a New Jersey corp.) (US) | 1998-10-28 | — | — | EP | claimed |
| EP-0868535-A2 | METHODS AND COMPOSITIONS FOR DETERMINING THE SEQUENCE OF NUCLEIC ACID MOLECULES | Rapigene, Inc. (US) | 1998-10-07 | — | — | EP | claimed |
| US-5688974-A | Process for the preparation of an endothelin antagonist | MERCK & CO., INC. (US) | 1997-11-18 | — | — | US | claimed |
| WO-1997027331-A9 | METHODS AND COMPOSITIONS FOR DETERMINING THE SEQUENCE OF NUCLEIC ACID MOLECULES | — | 1997-10-09 | — | — | WO | claimed |
| WO-1997027331-A2 | METHODS AND COMPOSITIONS FOR DETERMINING THE SEQUENCE OF NUCLEIC ACID MOLECULES | RAPIGENE, INC. (US) | 1997-07-31 | — | — | WO | claimed |
| WO-1997021700-A1 | PROCESS FOR THE PREPARATION OF AN ENDOTHELIN ANTAGONIST | MERCK & CO., INC. (US) | 1997-06-19 | — | — | WO | claimed |
| EP-0278176-B1 | Compounds having antitumour and antibacterial properties | WARNER LAMBERT CO (US) | 1994-03-09 | — | — | EP | claimed |
| EP-0338306-A2 | Halogen-substituted phenoxybenzyl compounds | BAYER AG (DE) | 1989-10-25 | — | — | EP | claimed |
| EP-0278176-A2 | Compounds having antitumour and antibacterial properties | WARNER-LAMBERT COMPANY (US) | 1988-08-17 | — | — | EP | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070203243-A1 | RESOLUTION OF ALPHA-(PHENOXY) PHENYLACETIC ACID DERIVATIVES | PAH, HPD, IDUA | KDM4E 1599/4885ALDH1A1 118/4885CHRM1 411/4885 |
| US-20120046308-A1 | NOVEL ALPHA-PHENOXYBENZENEACETIC ACID DERIVATIVE AND PHARMACEUTICAL PREPARATION COMPRISING SAME | PPARA, PPARG, PPARD | KDM4E 3100/4885ALDH1A1 1063/4885CHRM1 84/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.