SCHEMBL6608784

SCHEMBL6608784

c1ccc(-c2ccc(OC3CC3)cc2)cc1

nearest known ligand 0.58

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
NAAA Q02083 1/20 0.58
HRH1 P35367 3/20 0.55
EPHX2 P34913 2/20 0.48
SLC6A4 P31645 2/20 0.47
SLC6A2 P23975 2/20 0.47
SLC6A3 Q01959 2/20 0.47
MAP4K4 O95819 1/20 0.45
CHRNB2 P17787 1/20 0.45
CHRNB4 P30926 1/20 0.45
CHRNA3 P32297 1/20 0.45
CHRNA7 P36544 1/20 0.45
CHRNA4 P43681 1/20 0.45
CHRNA10 Q9GZZ6 1/20 0.45
CHRNA9 Q9UGM1 1/20 0.45
SMN1; SMN2 Q16637 1/20 0.45
MMP3 P08254 1/20 0.43
CYP3A4 P08684 1/20 0.42
TAAR1 Q96RJ0 1/20 0.42
HSD17B10 Q99714 1/20 0.42
TDP1 Q9NUW8 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10231904 0.90 NAAA (0.57) NAAAHRH1EPHX2SLC6A4SLC6A2
SCHEMBL5204218 0.86 HRH1 (0.79) NAAAHRH1SLC6A4SLC6A2SLC6A3
SCHEMBL3244625 0.86 NAAA (0.50) NAAAHRH1EPHX2SLC6A4SLC6A2
SCHEMBL29856 0.85 HRH1 (0.71) HRH1EPHX2SLC6A4SLC6A2SLC6A3
Ammonia Solution, Strong SCHEMBL8078606 0.83 HRH1 (0.68) HRH1EPHX2SLC6A4SLC6A2SLC6A3
SCHEMBL5390747 0.83 NAAA (0.47) NAAAHRH1EPHX2SLC6A4SLC6A2
SCHEMBL5375025 0.83 NAAA (0.47) NAAAHRH1EPHX2SLC6A4SLC6A2
SCHEMBL6573174 0.83 NAAA (0.47) NAAAHRH1EPHX2SLC6A4SLC6A2
SCHEMBL5375027 0.83 NAAA (0.47) NAAAHRH1EPHX2SLC6A4SLC6A2
SCHEMBL13703555 0.82 HRH1 (0.71) NAAAHRH1SLC6A4SLC6A2SLC6A3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1034164-B1 SUBSTITUTED BETA-ALANINE DERIVATIVES AS CELL ADHESION INHIBITORS MERCK & CO INC (US) 2004-05-19 EP claimed
EP-1034164-A4 SUBSTITUTED BETA-ALANINE DERIVATIVES AS CELL ADHESION INHIBITORS MERCK & CO INC (US) 2001-07-11 EP claimed
EP-1034164-A1 SUBSTITUTED BETA-ALANINE DERIVATIVES AS CELL ADHESION INHIBITORS Merck & Co., Inc. (US) 2000-09-13 EP claimed
WO-1999026921-A1 SUBSTITUTED β-ALANINE DERIVATIVES AS CELL ADHESION INHIBITORS MERCK & CO., INC. (US) 1999-06-03 WO claimed
EP-1034164-B1 SUBSTITUTED BETA-ALANINE DERIVATIVES AS CELL ADHESION INHIBITORS MERCK & CO INC (US) 2004-05-19 EP disclosed
US-6645939-B1 Very late antigen-4 (VLA) integrin antagonists; antiallergens, antiasthmatics, and antiinflammatory agents; multiple sclerosis, autoimmune disease treatment MERCK & CO., INC. 2003-11-11 US disclosed
EP-1034164-A4 SUBSTITUTED BETA-ALANINE DERIVATIVES AS CELL ADHESION INHIBITORS MERCK & CO INC (US) 2001-07-11 EP disclosed
WO-2000071572-A1 SUBSTITUTED BETA-ALANINE DERIVATIVES AS CELL ADHESION INHIBITORS MERCK & CO., INC. (US) 2000-11-30 WO disclosed
EP-1034164-A1 SUBSTITUTED BETA-ALANINE DERIVATIVES AS CELL ADHESION INHIBITORS Merck & Co., Inc. (US) 2000-09-13 EP disclosed
WO-1999026921-A1 SUBSTITUTED β-ALANINE DERIVATIVES AS CELL ADHESION INHIBITORS MERCK & CO., INC. (US) 1999-06-03 WO disclosed