Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 4/20 | 0.60 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.60 |
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.59 |
| ▸ | RAB9A | P51151 | 3/20 | 0.59 |
| ▸ | TP53 | P04637 | 3/20 | 0.59 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.59 |
| ▸ | NPC1 | O15118 | 2/20 | 0.59 |
| ▸ | ESR1 | P03372 | 1/20 | 0.59 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.57 |
| ▸ | MEN1 | O00255 | 2/20 | 0.57 |
| ▸ | MAPT | P10636 | 8/20 | 0.55 |
| ▸ | HPGD | P15428 | 3/20 | 0.53 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.53 |
| ▸ | HTT | P42858 | 1/20 | 0.53 |
| ▸ | LMNA | P02545 | 1/20 | 0.53 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.53 |
| ▸ | POLB | P06746 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6602387 | 0.93 | TSHR (0.59) | TSHRMCHR1SMN1; SMN2RAB9ATP53 | |
| SCHEMBL6602432 | 0.89 | TSHR (0.63) | TSHRMCHR1SMN1; SMN2RAB9ATP53 | |
| SCHEMBL6602378 | 0.87 | MCHR1 (0.64) | TSHRMCHR1SMN1; SMN2RAB9ATP53 | |
| SCHEMBL6926140 | 0.80 | MCHR1 (0.72) | MCHR1SMN1; SMN2RAB9ATP53KDM4E | |
| SCHEMBL6604698 | 0.79 | KMT2A (0.56) | MCHR1SMN1; SMN2RAB9AKDM4ENPC1 | |
| SCHEMBL6925692 | 0.79 | MCHR1 (0.92) | MCHR1 | |
| SCHEMBL6923947 | 0.79 | MCHR1 (0.66) | TSHRMCHR1ALDH1A1LMNAPOLB | |
| SCHEMBL6603549 | 0.79 | KMT2A (0.69) | MCHR1SMN1; SMN2RAB9ATP53KDM4E | |
| SCHEMBL6925370 | 0.79 | MCHR1 (0.71) | MCHR1SMN1; SMN2RAB9ATP53NPC1 | |
| SCHEMBL6923988 | 0.79 | MCHR1 (0.71) | MCHR1SMN1; SMN2RAB9ATP53NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1102535-A4 | COMPOUNDS AND METHODS | SMITHKLINE BEECHAM CORP (US) | 2004-09-29 | — | — | EP | disclosed |
| US-6399656-B1 | USING A BENZOPYRAN-3-CARBOXAMIDE COMPOUND | SMITHKLINE BEECHAM CORPORATION | 2002-06-04 | — | — | US | disclosed |
| EP-1102535-A2 | COMPOUNDS AND METHODS | SmithKline Beecham Corporation (US) | 2001-05-30 | — | — | EP | disclosed |
| WO-2000006085-A2 | COMPOUNDS AND METHODS | SMITHKLINE BEECHAM CORPORATION (US) | 2000-02-10 | — | — | WO | disclosed |