Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 4/20 | 0.59 |
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.58 |
| ▸ | RAB9A | P51151 | 3/20 | 0.58 |
| ▸ | TP53 | P04637 | 3/20 | 0.58 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.58 |
| ▸ | NPC1 | O15118 | 2/20 | 0.58 |
| ▸ | ESR1 | P03372 | 1/20 | 0.58 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.58 |
| ▸ | MAPT | P10636 | 8/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.56 |
| ▸ | MEN1 | O00255 | 2/20 | 0.56 |
| ▸ | HPGD | P15428 | 3/20 | 0.52 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.52 |
| ▸ | HTT | P42858 | 1/20 | 0.52 |
| ▸ | LMNA | P02545 | 1/20 | 0.52 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.52 |
| ▸ | POLB | P06746 | 1/20 | 0.52 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6608917 | 0.93 | TSHR (0.60) | TSHRSMN1; SMN2RAB9ATP53KDM4E | |
| SCHEMBL6602432 | 0.89 | TSHR (0.63) | TSHRSMN1; SMN2RAB9ATP53KDM4E | |
| SCHEMBL6602378 | 0.86 | MCHR1 (0.64) | TSHRSMN1; SMN2RAB9ATP53KDM4E | |
| SCHEMBL6899096 | 0.82 | MCHR1 (0.70) | MCHR1 | |
| SCHEMBL7614829 | 0.82 | MAPT (0.55) | SMN1; SMN2RAB9ATP53KDM4ENPC1 | |
| SCHEMBL6604033 | 0.80 | KMT2A (0.55) | SMN1; SMN2RAB9AKDM4ENPC1MAPT | |
| SCHEMBL6898088 | 0.80 | MCHR1 (0.67) | SMN1; SMN2RAB9ATP53NPC1ALDH1A1 | |
| SCHEMBL6921907 | 0.80 | MCHR1 (0.80) | MCHR1 | |
| SCHEMBL6896989 | 0.80 | MCHR1 (0.67) | SMN1; SMN2RAB9ATP53NPC1ALDH1A1 | |
| SCHEMBL6605524 | 0.80 | KMT2A (0.68) | TSHRSMN1; SMN2RAB9ATP53KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1102535-A4 | COMPOUNDS AND METHODS | SMITHKLINE BEECHAM CORP (US) | 2004-09-29 | — | — | EP | disclosed |
| EP-1102535-A2 | COMPOUNDS AND METHODS | SmithKline Beecham Corporation (US) | 2001-05-30 | — | — | EP | disclosed |
| WO-2000006085-A2 | COMPOUNDS AND METHODS | SMITHKLINE BEECHAM CORPORATION (US) | 2000-02-10 | — | — | WO | disclosed |