SCHEMBL6609213

SCHEMBL6609213

CN(CC(CCOS(=O)(=O)c1ccccc1)c1ccc(Cl)c(Cl)c1)C(=O)c1ccccc1

nearest known ligand 0.62

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
TACR2 P21452 17/20 0.62
TACR1 P25103 1/20 0.57

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4984205 0.90 TACR2 (0.62) TACR2TACR1
SCHEMBL7307909 0.84 TACR2 (0.60) TACR2TACR1
SCHEMBL6425161 0.82 TACR2 (0.65) TACR2TACR1
SCHEMBL4873822 0.82 TACR2 (0.70) TACR2TACR1
SCHEMBL8870644 0.82 TACR2 (0.70) TACR2TACR1
SCHEMBL4610521 0.82 TACR2 (0.70) TACR2TACR1
SCHEMBL14263854 0.82 TACR2 (0.70) TACR2TACR1
SCHEMBL6774605 0.81 TACR2 (0.69) TACR2TACR1
SCHEMBL8590824 0.80 TACR2 (0.51) TACR2TACR1
SCHEMBL7313105 0.80 TACR2 (0.67) TACR2TACR1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0997462-B1 NOVEL NAPHTHYRIDINE DERIVATIVES OR SALTS THEREOF NIPPON KAYAKU KK (JP) 2004-12-22 EP disclosed
US-6294547-B1 Naphthyridine deratives or salts thereof NIPPON KAYAKU KABUSHIKI KAISHA (JP) 2001-09-25 US disclosed
EP-0997462-A1 NOVEL NAPHTHYRIDINE DERIVATIVES OR SALTS THEREOF Nippon Kayaku Kabushiki Kaisha (JP) 2000-05-03 EP disclosed
US-5965580-A TREATMENT OF SUBSTANCE P- AND NEUROKININ-DEPENDENT DISORDERS SANOFI (FR) 1999-10-12 US disclosed
US-5939411-A PIPERIDINE DERIVATIVES SUBSTITUTED AT POSITION 4 WITH NEW FUNCTIONS OTHER THAN THOSE DESCRIBED PREVIOUSLY HAVE A HIGH AFFINITY FOR NEUROKININ RECEPTORS AND ARE USEFUL FOR TREATMENT OF SUBSTANCE P AND NEUROKININ DEPENDENT PATHOLOGIES SANOFI (FR) 1999-08-17 US disclosed
US-5830906-A Piperidine derivatives, process for obtaining them and pharmaceutical compositions containing them SANOFI (FR) 1998-11-03 US disclosed