Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIN1 | Q05586 | 4/20 | 0.37 |
| ▸ | GRIN2B | Q13224 | 4/20 | 0.37 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.33 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.31 |
| ▸ | PHGDH | O43175 | 1/20 | 0.31 |
| ▸ | ACACB | O00763 | 2/20 | 0.31 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.31 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.31 |
| ▸ | KCNK3 | O14649 | 1/20 | 0.30 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.30 |
| ▸ | PGR | P06401 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6610545 | 0.87 | GRIN1 (0.35) | GRIN1GRIN2BKCNH2HRH3TSHR | |
| SCHEMBL6610460 | 0.86 | GRIN1 (0.34) | GRIN1GRIN2BKCNH2TSHRHTT | |
| SCHEMBL6614452 | 0.84 | GRIN1 (0.38) | GRIN1GRIN2BKCNH2HRH3TSHR | |
| SCHEMBL6316375 | 0.81 | GRIN1 (0.37) | GRIN1GRIN2BHTTEPHX2 | |
| SCHEMBL6325320 | 0.67 | CCR5 (0.37) | GRIN1GRIN2BEPHX2 | |
| SCHEMBL6621396 | 0.67 | KCNH2 (0.51) | GRIN1GRIN2BKCNH2 | |
| SCHEMBL6614804 | 0.66 | KCNH2 (0.37) | GRIN1GRIN2BKCNH2 | |
| SCHEMBL6990992 | 0.66 | GRIN2B (0.59) | GRIN1GRIN2B | |
| SCHEMBL6323809 | 0.66 | CCR5 (0.36) | GRIN1GRIN2BEPHX2 | |
| SCHEMBL6624313 | 0.64 | TSHR (0.37) | GRIN1GRIN2BKCNH2TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1192154-B1 | BISPIDINE COMPOUNDS USEFUL IN THE TREATMENT OF CARDIAC ARRHYTHMIAS | ASTRAZENECA AB (SE) | 2004-03-17 | — | — | EP | claimed |