Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CASP3 | P42574 | 2/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.44 |
| ▸ | MDM4 | O15151 | 1/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | BACE1 | P56817 | 1/20 | 0.42 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29687297 | 1.00 | CASP3 (0.45) | CASP3KMT2AMDM2MDM4TP53 | |
| SCHEMBL29398965 | 1.00 | CASP3 (0.45) | CASP3KMT2AMDM2MDM4TP53 | |
| SCHEMBL25530715 | 1.00 | CASP3 (0.45) | CASP3KMT2AMDM2MDM4TP53 | |
| SCHEMBL25530710 | 0.91 | CASP3 (0.44) | CASP3KMT2AMDM2MDM4TP53 | |
| SCHEMBL16061957 | 0.91 | KMT2A (0.50) | CASP3KMT2AMDM2MDM4TP53 | |
| SCHEMBL23042740 | 0.91 | CASP3 (0.44) | CASP3KMT2AMDM2MDM4TP53 | |
| SCHEMBL29687418 | 0.91 | CASP3 (0.44) | CASP3KMT2AMDM2MDM4TP53 | |
| SCHEMBL29687298 | 0.91 | CASP3 (0.44) | CASP3KMT2AMDM2MDM4TP53 | |
| SCHEMBL14265315 | 0.90 | CASP3 (0.52) | CASP3KMT2AMDM2MDM4TP53 | |
| SCHEMBL29400810 | 0.90 | CASP3 (0.52) | CASP3KMT2AMDM2MDM4TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1212309-B1 | CASPASE INHIBITOR | LG CHEM INVESTMENT LTD (KR) | 2004-08-18 | — | — | EP | disclosed |
| US-6747050-B1 | INHIBITING THE ACTIVITY OF CASPASES, PREVENTING INFLAMMATION AND APOPTOSIS | LG CHEM INVESTMENT LTD. (KR) | 2004-06-08 | — | — | US | disclosed |
| EP-1212309-A4 | CASPASE INHIBITOR | LG CHEM INVESTMENT LTD (KR) | 2002-11-27 | — | — | EP | disclosed |
| EP-1212309-A1 | CASPASE INHIBITOR | LG Chem Investment, Ltd. (KR) | 2002-06-12 | — | — | EP | disclosed |
| WO-2001021600-A1 | CASPASE INHIBITOR | LG CHEM INVESTMENT LTD. (KR) | 2001-03-29 | — | — | WO | disclosed |
| WO-2001021599-A1 | CASPASE INHIBITOR | LG CHEMICAL LTD. (KR) | 2001-03-29 | — | — | WO | disclosed |