Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BCHE | P06276 | 9/20 | 0.50 |
| ▸ | MAOB | P27338 | 2/20 | 0.48 |
| ▸ | ACHE | P22303 | 3/20 | 0.48 |
| ▸ | CHRNA7 | P36544 | 2/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
| ▸ | NAMPT | P43490 | 1/20 | 0.43 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6609638 | 0.73 | BCHE (0.64) | BCHEMAOBACHECHRNA7 | |
| SCHEMBL12890021 | 0.73 | BCHE (0.69) | BCHEMAOBACHECHRNA7 | |
| SCHEMBL23500782 | 0.72 | ACACB (0.48) | BCHEMAPT | |
| SCHEMBL17392415 | 0.71 | NOTUM (0.55) | MAPT | |
| SCHEMBL17392419 | 0.71 | NOTUM (0.55) | MAPT | |
| SCHEMBL9427427 | 0.71 | BCHE (0.66) | BCHEMAOBACHECHRNA7 | |
| SCHEMBL12240583 | 0.71 | GAA (0.81) | NPC1RAB9AKDM4EALDH1A1MAPT | |
| SCHEMBL12407207 | 0.71 | NPC1 (0.54) | BCHEMAOBNPC1RAB9AMAPT | |
| SCHEMBL12407158 | 0.71 | NPC1 (0.58) | MAOBNPC1RAB9AMAPTTDP1 | |
| SCHEMBL12890653 | 0.71 | BCHE (0.64) | BCHEMAOBACHECHRNA7NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1463724-A1 | PYRROLIDONE CARBOXAMIDES | Actelion Pharmaceuticals Ltd. (CH) | 2004-10-06 | — | — | EP | disclosed |
| WO-2003059905-A1 | PYRROLIDONE CARBOXAMIDES | ACTELION PHARMACEUTICALS LTD (CH) | 2003-07-24 | — | — | WO | disclosed |