Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.45 |
| ▸ | MAPT | P10636 | 3/20 | 0.45 |
| ▸ | LMNA | P02545 | 2/20 | 0.45 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | STS | P08842 | 1/20 | 0.40 |
| ▸ | VEGFA | P15692 | 1/20 | 0.39 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.39 |
| ▸ | P2RX3 | P56373 | 1/20 | 0.39 |
| ▸ | ACKR3 | P25106 | 1/20 | 0.39 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.38 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.38 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.38 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.38 |
| ▸ | MET | P08581 | 1/20 | 0.38 |
| ▸ | SUV39H2 | Q9H5I1 | 2/20 | 0.38 |
| ▸ | CNR1 | P21554 | 1/20 | 0.37 |
| ▸ | SETD7 | Q8WTS6 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6608769 | 0.86 | ALDH1A1 (0.39) | ALDH1A1MAPTLMNAMEN1KMT2A | |
| SCHEMBL29257897 | 0.80 | ALDH1A1 (0.56) | ALDH1A1MAPTLMNAMEN1KMT2A | |
| SCHEMBL213732 | 0.79 | HRH2 (0.45) | ALDH1A1MAPTLMNAMEN1KMT2A | |
| SCHEMBL15567036 | 0.79 | KMT2A (0.50) | ALDH1A1MAPTLMNAMEN1KMT2A | |
| SCHEMBL2735430 | 0.78 | KDM4E (0.53) | ALDH1A1MAPTLMNAMEN1KMT2A | |
| SCHEMBL5474611 | 0.77 | ALDH1A1 (0.58) | ALDH1A1MAPTLMNAVEGFAEGLN1 | |
| SCHEMBL26122711 | 0.76 | ALDH1A1 (0.55) | ALDH1A1MAPTLMNAMEN1KMT2A | |
| SCHEMBL13648180 | 0.76 | ALDH1A1 (0.48) | ALDH1A1MAPTLMNAMEN1KMT2A | |
| SCHEMBL21253089 | 0.75 | KDM4E (0.55) | ALDH1A1MAPTLMNAMEN1KMT2A | |
| SCHEMBL31487436 | 0.75 | MAPT (0.59) | ALDH1A1MAPTLMNAMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0706524-B1 | PROCESSES AND INTERMEDIATES FOR THE PREPARATION OF 5- 2-(4-(BENZOISOTHIAZOL-3-YL)-PIPERAZIN-1-YL)ETHYL]-6-CHLORO-1,3-DIHYDRO-INDOL-2-ONE | PFIZER (US) | 2004-09-22 | — | — | EP | disclosed |
| EP-0706524-A1 | PROCESSES AND INTERMEDIATES FOR THE PREPARATION OF 5- 2-(4-(BENZOISOTHIAZOL-3-YL)-PIPERAZIN-1-YL)ETHYL]-6-CHLORO-1,3-DIHYDRO-INDOL-2-ONE | PFIZER INC. (US) | 1996-04-17 | — | — | EP | disclosed |
| WO-1995000510-A1 | PROCESSES AND INTERMEDIATES FOR THE PREPARATION OF 5-[2-(4-(BENZOISOTHIAZOL-3-YL)-PIPERAZIN-1-YL)ETHYL]-6-CHLORO-1,3-DIHYDRO-INDOL-2-ONE | PFIZER INC. (US) | 1995-01-05 | — | — | WO | disclosed |
| US-5359068-A | Processes and intermediates for the preparation of 5-[2-(4-(benzoisothiazol-3-yl)-piperazin-1-yl)ethyl]-6-chloro-1,3-dihydro-indol-2-one | PFIZER INC. (US) | 1994-10-25 | — | — | US | disclosed |