SCHEMBL6609670

SCHEMBL6609670

CCCN(CCF)Cc1sc(Nc2c(Cl)cc(Cl)cc2Cl)nc1C(F)(F)F

nearest known ligand 0.92

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
CRHR1 P34998 20/20 0.92
CRHR2 Q13324 1/20 0.75

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6605233 0.96 CRHR1 (1.00) CRHR1CRHR2
SCHEMBL6611821 0.92 CRHR1 (1.00) CRHR1CRHR2
SCHEMBL6606167 0.91 CRHR1 (0.90) CRHR1CRHR2
SCHEMBL6928009 0.90 CRHR1 (0.88) CRHR1CRHR2
SCHEMBL6606622 0.88 CRHR1 (1.00) CRHR1CRHR2
SCHEMBL6605753 0.88 CRHR1 (1.00) CRHR1CRHR2
SCHEMBL6612107 0.88 CRHR1 (0.84) CRHR1CRHR2
SCHEMBL6606842 0.87 CRHR1 (1.00) CRHR1CRHR2
SCHEMBL6608912 0.87 CRHR1 (1.00) CRHR1CRHR2
SCHEMBL6607202 0.87 CRHR1 (0.87) CRHR1CRHR2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1320365-A4 SUBSTITUTED AZOLE DERIVATIVES AS INHIBITORS OF CORTICOTROPIN RELEASING FACTOR BRISTOL MYERS SQUIBB CO (US) 2004-03-17 EP claimed
EP-1320365-A1 SUBSTITUTED AZOLE DERIVATIVES AS INHIBITORS OF CORTICOTROPIN RELEASING FACTOR Bristol-Myers Squibb Company (US) 2003-06-25 EP claimed
WO-2002024200-A1 SUBSTITUTED AZOLE DERIVATIVES AS INHIBITORS OF CORTICOTROPIN RELEASING FACTOR BRISTOL-MYERS SQUIBB COMPANY (US) 2002-03-28 WO claimed